32767-46-7

Basic information

• Product Name: METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE
• Synonyms: methyl 4,4-dimethyl-2-oxocyclohexane-1-carboxylate;5,5-Dimethyl-2-(methoxycarbonyl)cyclohexanone;4,4-Dimethyl-2-oxocyclohexanecarboxylic acid methyl ester
• CAS NO: 32767-46-7
• Molecular Formula: C₁₀H₁₆O₃
• Molecular Weight: 184.23224
• Mol File: 32767-46-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 245.2±33.0 °C(Predicted)
• Appearance: /
• Density: 1.029±0.06 g/cm3(Predicted)
• PKA: 12.10±0.40(Predicted)
• CAS DataBase Reference: METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE(32767-46-7)
• EPA Substance Registry System: METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE(32767-46-7)

Safety Data

• Hazardous Substances Data: 32767-46-7(Hazardous Substances Data)

Usage

Description

METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE is an organic compound that serves as a key reactant in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which allows it to participate in a range of chemical reactions and contribute to the development of new therapeutic agents.

Uses

Used in Pharmaceutical Industry:
METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE is used as a reactant in the synthesis of pyrido[3'',2'':4,5]furo[3,2-d]pyrimidines. These compounds are studied as potent phosphodiesterase type 4 (PDE4) inhibitors, which have potential applications in the treatment of asthma and chronic obstructive pulmonary disease (COPD). METHYL 4,4-DIMETHYL-2-OXOCYCLOHEXANECARBOXYLATE's role in the synthesis process is crucial for the development of these potential therapeutic agents, highlighting its importance in the pharmaceutical industry.

Upstream product

• 186581-53-3 diazomethane 
• 2979-19-3 3,3-dimethylcyclohexanone 
• 124-38-9 carbon dioxide 
• 616-38-6 carbonic acid dimethyl ester 
• 4694-17-1 5,5-dimethlycyclohex-2-en-1-one 
• 1193-18-6 3-methylcyclohexen-2-one 
• 17640-15-2 methyl cyanoformate 

Downstream Products

• 86399-15-7 2-(2-Bromo-ethyl)-5,5-dimethyl-cyclohexanone 
• 78661-18-4 2-Methoxycarbonyl-5,5-dimethyl-2-(m-methoxyphenyl)-cyclohexanone 
• 142778-92-5 3-(1-carbomethoxy-2-oxo-4,4-dimethylcyclohexyl)propanal 
• 185248-59-3 2-(Diethoxy-phosphoryloxy)-4,4-dimethyl-cyclohex-1-enecarboxylic acid methyl ester 
• 18088-97-6 (2,4,4-trimethyl-1-cyclohexen-1-yl)carboxylic acid 
• 103985-40-6 (2,4,4-trimethyl-1-cyclohexen-1-yl)methanol 
• 5939-87-7 (2,4,4-trimethyl-1-cyclohexene)carbaldehyde 
• 17920-96-6 methyl β-cyclolavandulate 
• 854720-02-8 4,4-cimethylcyclohex-1-ene-1-carboxylic acid 
• 32767-49-0 4,4-Dimethyl-cyclohex-1-enecarboxylic acid methyl ester 
• 32737-97-6 2c-hydroxy-4,4-dimethyl-cyclohexane-r-carboxylic acid hydrazide 
• 32737-97-6 2t-hydroxy-4,4-dimethyl-cyclohexane-r-carboxylic acid hydrazide 
• 917911-19-4 C₁₀H₁₇NO₂ 
• 1228780-46-8 methyl 4,4-dimethyl-2-(((trifluoromethyl)sulfonyl)oxy)cyclohex-1-ene-1-carboxylate 

Relevant articles and documents

Synthesis, characterization and in vitro antibacterial evaluation of 1-(7,7-dimethyl-2-morpholino-5,6,7,8-tetrahydroquinazolin-4-yl)piperidine-4-carboxamide derivatives

A series of six novel 1-(7,7-dimethyl-2-morpholino-5,6,7,8-tetrahydroquinazolin-4-yl)piperidine-4-carboxamide derivatives has been synthesized and characterized using various spectral techniques (1H and 13C NMR, LCMS, IR). The antiba

Synthesis and antiviral study of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl) morpholine derivatives

Abstract: A series of 4-(7,7-dimethyl-4-(piperazin-1-yl)-5,6,7,8-tetrahydroquinazolin-2-yl)morpholine substituted sulfonamide and urea derivatives has been synthesized and characterized using spectral techniques. The antiviral activity of these compounds

Efficient synthesis of carbon-11 labelled acylsulfonamides using [11C]CO carbonylation chemistry

Herein, a novel method for carbon-11 labeling of acyl sulfonamides by a one-step insertive [11C]CO carbonylative cross-coupling reaction between aryl halides and sulfonamides is presented. Various model compounds as well as drug molecules LY573636 (tasisulam) and ABT-199 were obtained in excellent yields. This method provides a valuable and widely applicable contribution to the continuously expanding radiochemical toolbox for PET research.

Sulfonamide derivative and application thereof in pharmacy

The invention relates to a sulfonamide derivative and a pharmaceutical composition containing the same, and an application of the sulfonamide derivative and the pharmaceutical composition of the sulfonamide derivative in drug preparation, specifically the application in drug preparation of a BCL-2 family protein antagonist and the application in treatment of cancers.