32803-73-9

Basic information

• Product Name: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester
• Synonyms: 3-Phenyl-3-chloro-2-oxopropionic acid methyl ester;methyl phenylchloropyruvate;methyl 3-chloro-2-oxo-3-phenylpropanoate;3-phenyl-3-chloro-2-ketopropionic acid methyl ester;methyl 3-phenyl-3-chloro-2-ketopropionate;2-oxo-3-phenyl-3-chloropropionic acid methyl ester
• CAS NO: 32803-73-9
• Molecular Formula: C10H9ClO3
• Molecular Weight: 212.633
• Mol File: 32803-73-9.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(32803-73-9)
• EPA Substance Registry System: Benzenepropanoic acid, b-chloro-a-oxo-, methyl ester(32803-73-9)

Safety Data

• Hazardous Substances Data: 32803-73-9(Hazardous Substances Data)

Upstream product

• 116-54-1 dichloroacetic acid methyl ester 
• 100-52-7 benzaldehyde 
• 29653-30-3 dimethyl 2,2-dichloromalonate 
• 90179-18-3 (erythro-threo)-methyl-2-cyano-3-fluoro-2-hydroxy-3-phenylpropanoate 

Downstream Products

• 115174-41-9 5-Phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 
• 119804-65-8 3-phenyl-1,4-dithi-2-ene-2-carboxylic acid methyl ester 
• 86217-47-2 3-phenyl-3-hydroxypropionic acid hydrazide 
• 328402-05-7 methyl (2S,3R)-3-chloro-2-hydroxy-3-phenylpropanoate 
• 328402-04-6 methyl (2S,3S)-(+)-3-chloro-2-hydroxy-3-phenylpropanoate 
• 771585-06-9 4-hydroxy-4-methoxycarbonyl-2-(thiazol-2-yl)imino-3,5-diphenylthiazolidine 
• 183858-18-6 4-hydroxy-4-methoxycarbonyl-3,5-diphenyl-2-phenyl-iminothiazolidine 
• 119804-64-7 2-carbomethoxy-3-phenyl-5,6-dihydro-1,4-oxathiine 
• 123822-56-0 2-Methoxycarbonyl-2-styryloxytriphenylphosphonium chloride 
• 124831-91-0 3-(α-chlorobenzyl)-1,2-dihydroxyquinoxalin-2-one 
• 133415-16-4 methyl 2,5-diphenylthiazole-4-carboxylate 
• 115174-39-5 2-Amino-5-phenyl-thiazole-4-carboxylic acid methyl ester; hydrochloride 
• 133415-15-3 methyl 2-methyl-5-phenylthiazole-4-carboxylate 
• 151999-02-9 2-hydroxy-2-(α-chlorobenzyl)-3-oxo-1,4-oxazane 

Relevant articles and documents

Intermolecular cyclocondensation of arylchloropyruvates in the synthesis of 2,3-dihydrofuran-3,5-dicarboxylic acid derivatives

Methyl arylchloropyruvates undergo intermolecular self-condensation in the presence of a catalytic amount of a base under high-temperature conditions (~250°C) with the formation of 3,4-diaryl-2-oxo-2,3-dihydrofuran-3,5-dicarboxylic acid derivatives.

OXAZOLE AND THIAZOLE DERIVATIVES AS ALX RECEPTOR AGONISTS

The invention relates to oxazole and thiazole derivatives of formula (I), wherein A, E, X, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

PIPERIDINE AND PYROOLIDINE COMPOUNDS

The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.