328083-79-0

Basic information

• Product Name: 4-TERT-BUTOXYCARBONYLAMINO-1-(3,4-DICHLOROBENZYL)PIPERIDINE
• Synonyms: 4-TERT-BUTOXYCARBONYLAMINO-1-(3,4-DICHLOROBENZYL)PIPERIDINE;tert-Butyl N-[1-[(3,4-dichlorophenyl)methyl]-4-piperidyl]carbamate
• CAS NO: 328083-79-0
• Molecular Formula: C₁₇H₂₄Cl₂N₂O₂
• Molecular Weight: 359.29066
• Mol File: 328083-79-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 450.5°C at 760 mmHg
• Flash Point: 226.3°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 2.61E-08mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 4-TERT-BUTOXYCARBONYLAMINO-1-(3,4-DICHLOROBENZYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTOXYCARBONYLAMINO-1-(3,4-DICHLOROBENZYL)PIPERIDINE(328083-79-0)
• EPA Substance Registry System: 4-TERT-BUTOXYCARBONYLAMINO-1-(3,4-DICHLOROBENZYL)PIPERIDINE(328083-79-0)

Safety Data

• Hazardous Substances Data: 328083-79-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H24Cl2N2O2/c1-17(2,3)23-16(22)20-13-6-8-21(9-7-13)11-12-4-5-14(18)15(19)10-12/h4-5,10,13H,6-9,11H2,1-3H3,(H,20,22)

Upstream product

• 73874-95-0 (piperidin-4-yl)carbamic acid tert-butyl ester 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 18880-04-1 3,4-dichlorobenzyl bromide 
• 73889-19-7 tert-butyl (1-benzylpiperidin-4-yl)carbamate 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 92539-28-1 1-(3,4-Dichlorobenzyl)-4-piperidinylamine 
• 701237-08-3 4-(tert-butoxycarbonyl)(methyl)amino-1-(3,4-dichlorobenzyl)piperidine 
• 353791-88-5 2-bromo-N-[1-(3,4-dichloro-benzyl)-piperidin-4-yl]-acetamide 
• 290363-23-4 2-[(6-amino-2-benzothiazolyl)thio]-N-[1-[(3,4-dichlorophenyl)methyl]-4-piperidinyl]acetamide 
• 290363-29-0 N-[1-(3,4-dichlorobenzyl)piperidin-4-yl]-(6-ethoxycarbonyl-2-benzothiazolylthio)acetamide 
• 328084-04-4 1-(3,4-dichlorobenzyl)-4-(methylamino)piperidine 
• 625080-89-9 N-[1-(3,4-dichlorobenzyl)piperidin-4-yl]-(6-carboxyl-2-benzothiazolylthio)acetamide 

Relevant articles and documents

Design and development of novel thiazole-sulfonamide derivatives as a protective agent against diabetic cataract in Wistar rats via inhibition of aldose reductase

In recent years, ALR2 (aldose reductase) inhibitors have attracted attention for their effective ability to reduce the progression of diabetes-associated cataracts. Therefore, in the present article, we intended to develop novel thiazole-sulfonamide hybrids as a potent inhibitor of ALR2. These molecules significantly inhibited the ALR2 level in the rat lenses homogenate, where the most potent compound 7b showed activity comparable to sorbinil as standard. In Wistar rats, compound 7b improved the insulin level and body weight of the experimental animal together with a reduction in the glucose output. Compound 7b showed a significant reduction in the expression of ALR2 in rat lenses in western blot analysis.

NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA

The invention provides 1 -benzyl- 4 -piperidinamines of the general formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are useful in the treatment of respiratory diseses such a

Structure-activity relationships of 2-(benzothiazolylthio)acetamide class of CCR3 selective antagonist

The structure activity relationships of novel selective CCR3 receptor antagonists, 2-(benzothiazolylthio)acetamimde derivatives were described. A lead structure (1a) was discovered from the screening of the focused library that was based on the structure