32828-81-2 Usage
Description
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide is a complex organic compound characterized by its unique molecular structure. It is a derivative of benzene dicarboxamide with two pyridine-based substituents and a methoxy group, which may contribute to its potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide is used as a dual inhibitor for thromboxane A2 and thromboxane A2 synthase, playing a crucial role in the treatment of thrombosis. Its ability to selectively inhibit thromboxane synthesis and block platelet thromboxane receptors without affecting prostaglandin synthesis makes it a valuable compound in the development of antithrombotic agents.
Used in Aptamer Development:
In the field of molecular biology, 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide is used in the development of aptamers for targeting coagulation factor XIII. This application highlights its potential in the creation of targeted therapies for various medical conditions.
Used in Dermatological Applications:
4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide is also utilized as a keratolytic agent, which helps in the treatment of various skin conditions by promoting the shedding of dead skin cells and improving skin texture.
Brand Name:
While the provided materials do not specify a brand name for 4-Methoxy-N,N'-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide, it is worth noting that Picotamide, a compound with similar applications, is marketed under the brand name Plactidil.
Originator
Manetti-Roberts (Beecham (Italy)
References
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85
Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439
Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77
Check Digit Verification of cas no
The CAS Registry Mumber 32828-81-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,8,2 and 8 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 32828-81:
(7*3)+(6*2)+(5*8)+(4*2)+(3*8)+(2*8)+(1*1)=122
122 % 10 = 2
So 32828-81-2 is a valid CAS Registry Number.
32828-81-2Relevant articles and documents
Preparation method of picotamide
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, (2021/01/25)
The invention provides a method for preparing picotamide, which comprises the following steps: taking dimethyl 4-hydroxyl isophthalate as a raw material, carrying out methyl etherification reaction toobtain dimethyl 4-methoxy isophthalate; then, carrying out hydrolysis reaction to obtain 4-methoxy isophthalic acid; and finally, carrying out amidation reaction to obtain picotamide. Compared with atraditional method, the preparation method has the advantages of short synthesis steps, simplicity and convenience in operation, high reaction speed, high yield and the like. Besides, the raw materials required by the method are extracted from waste residues generated in industrial production, the extraction method is simple, the resource utilization rate is increased, the environmental pollutionis reduced, the production cost is reduced, and the method is suitable for large-scale industrial production.
