32864-38-3 Usage
Description
TERT-BUTYL ETHYL MALONATE is a clear colorless liquid that serves as a versatile reagent in organic synthesis and is particularly useful in the preparation of polar ester-functionalized aliphatic polysulfone.
Uses
Used in Polymer Industry:
TERT-BUTYL ETHYL MALONATE is used as a reagent for the synthesis of polar ester-functionalized aliphatic polysulfone, a material with remarkable thermal stability. This application is significant for creating polymers with enhanced properties for various industrial applications.
Used in Organic Synthesis:
TERT-BUTYL ETHYL MALONATE is also used as a valuable reagent in organic synthesis, where it contributes to the development of new compounds and materials with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 2114, 1974 DOI: 10.1021/jo00928a032
Purification Methods
A likely impurity is monoethyl malonate; check IR for OH bands at 3330 br cm-1 . To ca 50g of ester add ice cold NaOH (50g in 200mL of H2O and 200g of ice). Swirl a few times (filter off ice if necessary), place it in a separating funnel and extract with 2 x 75mL of Et2O. Dry the extract (MgSO4) (since traces of acid decompose the t-Bu group of the ester, the distillation flask has to be washed with aqueous NaOH, rinsed with H2O and allowed to dry). Addition of some K2CO3 or MgO before distilling is recommended to inhibit decomposition. Distil it under reduced pressure through a 10cm Vigreux column (p 11). Decomposition is evidenced by severe foaming due to autocatalytic decomposition and cannot be prevented from accelerating except by stopping the distillation and rewashing the distillation flask with alkali again. [Breslow et al. J Am Chem Soc 66 1287 1944, Hauser et al. J Am Chem Soc 64 2714 1942, Strube Org Synth Coll Vol IV 417 1963, Stube Org Synth 37 35 1957, Beilstein 2 IV 1884.]
Check Digit Verification of cas no
The CAS Registry Mumber 32864-38-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,8,6 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 32864-38:
(7*3)+(6*2)+(5*8)+(4*6)+(3*4)+(2*3)+(1*8)=123
123 % 10 = 3
So 32864-38-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H16O4/c1-5-12-7(10)6-8(11)13-9(2,3)4/h5-6H2,1-4H3
32864-38-3Relevant articles and documents
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Hauser,Abramovitch,Adams
, p. 2714 (1942)
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Synthesis of α-Aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates
Shang, Rui,Ji, Dong-Sheng,Chu, Ling,Fu, Yao,Liu, Lei
supporting information; experimental part, p. 4470 - 4474 (2011/06/24)
Worth its salt: The palladium-catalyzed decarboxylative coupling of the cyanoacetate salt as well as its mono- and disubstituted derivatives with aryl chlorides, bromides, and triflates is described (see scheme). This reaction is potentially useful for the preparation of a diverse array of α-aryl nitriles and has good functional group tolerance. S-Phos=2-(2,6- dimethoxybiphenyl)dicyclohexylphosphine), Xant-Phos=4,5-bis(diphenylphosphino)- 9,9-dimethylxanthene. Copyright
NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
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Page/Page column 29, (2009/10/01)
The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.