3289-47-2

Basic information

• Product Name: 4-Pyrimidinamine, 2-methoxy- (9CI)
• Synonyms: 4-Pyrimidinamine, 2-methoxy- (9CI);4-AMINO-2-METHOXYPYRIMIDINE;2-methoxypyrimidin-4-amine;2-O-Methylcytosine;(2-methoxypyrimidin-4-yl)amine;4-Pyrimidinamine, 2-methoxy-;2-Methoxy-4-PyriMidinaMine;2-Methoxycytosine
• CAS NO: 3289-47-2
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 3289-47-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 174 °C
• Boiling Point: 294.4 °C at 760 mmHg
• Flash Point: 131.9 °C
• Appearance: /
• Density: 1.224
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.97±0.10(Predicted)
• CAS DataBase Reference: 4-Pyrimidinamine, 2-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinamine, 2-methoxy- (9CI)(3289-47-2)
• EPA Substance Registry System: 4-Pyrimidinamine, 2-methoxy- (9CI)(3289-47-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 3289-47-2(Hazardous Substances Data)

Usage

Description

4-Pyrimidinamine, 2-methoxy(9CI) is a pyrimidine derivative characterized by the presence of a methoxy group at the C-2 position and an amine group at the C-4 position. 4-Pyrimidinamine, 2-methoxy(9CI) belongs to the class of organic compounds and exhibits unique chemical properties due to its structural features.

Uses

Used in Pharmaceutical Industry:
4-Pyrimidinamine, 2-methoxy(9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structural features make it a valuable building block for the development of new drugs with potential applications in treating different diseases.
Used in Chemical Research:
In the field of chemical research, 4-Pyrimidinamine, 2-methoxy(9CI) serves as a key compound for studying the reactivity and properties of pyrimidine derivatives. Researchers can use this compound to explore new reaction pathways and develop novel synthetic methods for the preparation of other pyrimidine-based molecules.
Used in Material Science:
4-Pyrimidinamine, 2-methoxy(9CI) can be utilized in the development of advanced materials with specific properties, such as optoelectronic materials or catalysts. Its unique structure and functional groups can be exploited to design materials with tailored properties for various applications.
Used in Agrochemical Industry:
4-Pyrimidinamine, 2-methoxy(9CI) may also find applications in the agrochemical industry as a precursor for the synthesis of pesticides or other agrochemicals. Its structural features can be exploited to develop new compounds with improved efficacy and selectivity in controlling pests and diseases in agriculture.

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 67-56-1 methanol 
• 77772-57-7 N⁴-benzoyl-2',3'-O-(triphenylphosphoranediyl)-O²,5'-cyclocytidine 
• 124-41-4 sodium methylate 
• 71-30-7 Cytosine 
• 194419-92-6 Methanesulfonic acid (S)-2-(diethoxy-phosphorylmethoxy)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester 
• 7461-50-9 2-chloropyrimidin-4-amine 
• 61445-73-6 (4-amino-pyrimidin-2-ylsulfanyl)-acetic acid 
• 76064-23-8 3-hydroxyacrylonitrile sodium salt 
• 52328-05-9 O-methylisourea hemisulfate 
• 51542-23-5 O-methylisourea sulfate monomethyl ester salt 

Downstream Products

• 3346-06-3 4-(4-nitro-benzenesulfonylamino)-1H-pyrimidin-2-one 
• 71-30-7 Cytosine 
• 51421-93-3 2-Methoxy-4-fluor-pyrimidin 
• 148214-62-4 2-methoxy-7H-pyrrolo<2,3-d>pyrimidine 
• 959240-72-3 4-bromo-2-methoxypyrimidine 
• 51421-99-9 4-chloro-2-methoxy-pyrimidine 
• 25902-86-7 2-Methoxy-4-hydroxypyrimidin 
• 1431650-73-5 N-(2-methoxypyrimidin-4-yl)-2-methyl-5-(2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide 
• 53166-66-8 N-(2-methoxypyrimidin-4-yl)benzamide 

Relevant articles and documents

Process for synthesis of cytosine

The invention discloses a process for synthesizing cytosine. A 3-hydroxyacrylonitrile compound and an O-methylisourea compound or an S-methylisothiourea compound or an S-ethylisothiourea compound or an S-benzylisothiourea compound are used as raw materials. The process comprises the steps of adding a catalyst and an organic solvent into a reaction kettle, stirring, and then adding the raw materials; heating the mixture to be 50-90 DEG C, and reacting for 8-12 hours; evaporating the solvent to obtain an intermediate; adding concentrated hydrochloric acid into the intermediate, heating to be 70-100 DEG C, and preserving the heat for 1-2 hours; adding water, performing hot filtration, and cooling the obtained filtrate to room temperature; dripping a sodium hydroxide solution into the filtrate to adjust the pH value to be 7-7.5, and cooling to 10-15 DEG C; filtering after cooling, washing, and drying to obtain the cytosine. The process has the advantages that the process steps are simple, the production period is short, and the cost is low; the conversion rate of the raw materials is high, and the synthesized product is good in quality and high in yield, so that the process is suitable for industrialized production.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

PYRIMIDINE DERIVATIVES

A compound of the following formula: wherein R1, R2, R3, R4, R5,T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.