329-78-2

Basic information

• Product Name: 1-(4-Chlorophenyl)-2-fluoroethanone
• Synonyms: 1-(4-chlorophenyl)-2-fluoroethanone;2-FLUORO-4'-CHLOROACETOPHENONE;4-CHLOROPHENACYLFLUORIDE;2-Chloro-4'-Fluoroacetophenone 4-Fluoro-alpha-Chloroacetophenone;4-Fluoro-α-chloroacetophenone;4-Fluoro-a-Chloroacetophenone;Ethanone, 1-(4-chlorophenyl)-2-fluoro- (9CI);4-Fluoro-a-chloroacetophenone/Fluorochloroacetophenone
• CAS NO: 329-78-2
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.58
• Product Categories: ACETYLHALIDE
• Mol File: 329-78-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 260.3 °C at 760 mmHg
• Flash Point: 111.2 °C
• Appearance: /
• Density: 1.247 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(4-Chlorophenyl)-2-fluoroethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Chlorophenyl)-2-fluoroethanone(329-78-2)
• EPA Substance Registry System: 1-(4-Chlorophenyl)-2-fluoroethanone(329-78-2)

Safety Data

• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1759
• Hazardous Substances Data: 329-78-2(Hazardous Substances Data)

Usage

General Description

1-(4-Chlorophenyl)-2-fluoroethanone is a chemical compound with the molecular formula C8H7ClF. It belongs to the class of ketones and contains a phenyl ring with a chlorine substituent and a fluorine atom attached to the ethanone group. 1-(4-Chlorophenyl)-2-fluoroethanone is commonly used in organic synthesis and medicinal chemistry as a building block for the creation of various pharmaceuticals, agrochemicals, and other fine chemicals. It is important to handle this compound with proper care and follow all safety protocols due to its potential health hazards and reactivity.

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 108-90-7 chlorobenzene 
• 413598-38-6 [(E)-1-(4-Chloro-phenyl)-2-fluoro-vinyloxy]-trimethyl-silane 
• 914801-65-3 N-(1-(4-chlorophenyl)-2-fluoroethylidene)isopropylamine 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 655-54-9 1-(4-chlorophenyl)-2,2-difluoropent-4-en-1-ol 
• 243845-56-9 2,2-difluoro-1-(4'-chloro-phenyl)-1-trimethylsiloxyethene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 99-91-2 para-chloroacetophenone 
• 459-72-3 ethyl 2-fluoroacetate 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1073-67-2 4-vinylbenzyl chloride 
• 331238-93-8 ADC₁₁₃ 
• 1354970-09-4 1-(1-azido-2-iodoethyl)-4-chlorobenzene 

Downstream Products

• 329-77-1 1-(4-chlorophenyl)-2-fluoroethanol 
• 1312213-34-5 2-(4-chlorophenyl)-3-fluoro-5,6,7,8-tetrahydro-4-phenyl-[1]benzothieno[2,3-b]pyridine 
• 1312213-29-8 2-(4-chlorophenyl)-3-fluoro-4-methylquinoline 
• 1312213-18-5 2-(4-chlorophenyl)-3-fluoro-4-phenylquinoline 
• 1415315-18-2 C₁₂H₁₄ClF 
• 1446417-86-2 1-(4-chlorophenyl)-2-fluoroethan-1-ol 
• 1261174-88-2 1-(4-chlorophenyl)-2-fluoroethan-1-ol 
• 99-91-2 para-chloroacetophenone 

Relevant articles and documents

A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones

Hydrodefluorination is one of the most promising chemical strategies to degrade perfluorochemicals into partially fluorinated compounds. However, controlled progressive hydrodefluorination remains a significant challenge, owing to the decrease in the stre

Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation

Cesium carbonate (Cs2CO3)-mediated decarboxylative fluorination of β-ketoacids using NFSI in the MeCN/H2O mixed solvent system affords α-fluoroketones with a broad scope. Both electron-rich and electron-deficient α-non-substituted β-ketoacids are amenable to this protocol. The mechanistic study indicates that the reaction proceeds through electrophilic fluorination followed by decarboxylation, which is different from the decarboxylative fluorination of normal carboxylic acids.

Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation

An efficient and mild fluorination of vinyl azides for the synthesis of α-fluoroketones is described. The mechanistic studies indicated that a single-electron transfer (SET) and a subsequent fluorine atom transfer process could be involved in the reaction.