330-81-4

Basic information

• Product Name: L-Phenylalanine, N-acetyl-4-fluoro-
• CAS NO: 330-81-4
• Molecular Formula: C11H12FNO3
• Molecular Weight: 225.22
• Mol File: 330-81-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-acetyl-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-acetyl-4-fluoro-(330-81-4)
• EPA Substance Registry System: L-Phenylalanine, N-acetyl-4-fluoro-(330-81-4)

Safety Data

• Hazardous Substances Data: 330-81-4(Hazardous Substances Data)

Upstream product

• 1132-68-9 L-4-fluorophenylalanine 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 176896-72-3 (S)-methyl 2-amino-3-(4-fluorophenyl)propanoate hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 125772-83-0 (Z)-4-(4-fluorobenzylidene)-2-methyloxazol-5(4H)-one 
• 17481-06-0 rac-Ac-p-F-Phe-OH 
• 87586-97-8 N-acetyl-(R,S)-4-fluorophenylalanine methyl ester 

Downstream Products

• 1132-68-9 L-4-fluorophenylalanine 

Relevant articles and documents

GRANZYME B DIRECTED IMAGING AND THERAPY

Provided herein are heterocyclic compounds useful for imaging Granzyme B. Methods of imaging Granzyme B, combination therapies, and kits comprising the Granzyme B imaging agents are also provided.

Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies

In this study, a series of pyrazole-based structural analogues of GGTI-DU40 (1) have been synthesized and biologically evaluated for geranylgeranyltransferase 1 (GGT1) and farnesyltransferase (FT) inhibition. The screening results revealed that 2 (IC50?=?2.4?μM) and 5 (IC50?=?3.1?μM) are potent GGT1 inhibitors (GGTIs), possessing higher inhibitory activity compared to the control compound 1 (IC50?=?3.3?μM). The anti-proliferative efficacy of these compounds was further assayed against MDA-MB-231?cells which indicated a significantly higher activity of 2 (IC50?=?7.6?μM) compared to 1 (IC50?=?23.0?μM). To examine the capacity of the synthesized compounds to inhibit GGT1 in an intact cell, western blot analysis was performed on the MDA-MB-231?cell line, which revealed very high inhibitory cellular activity of 2 and 5 and demonstrated their capacity to inhibit prenylation of endogenous proteins. Molecular docking studies of 2 against the crystal structure of GGT1 complexed with a geranylgeranyl pyrophosphate (GGPP) Analog and a CaaX (C?=?cysteine, aa?=?aliphatic amino acids, and X?=?any amino acid) portion of the KKKSKTKCVIL peptide substrate revealed several hydrogen bonding interactions and π-π contacts between 2 and the binding pocket of GGT1. Together these data suggest that compound 2 could proceed to in?vivo investigation to further assess its efficacy and cytotoxicity.

Resolution of N-protected amino acid esters using whole cells of Candida parapsilosis ATCC 7330

Whole cells of Candida parapsilosis ATCC 7330 were used for the resolution of N-acetyl amino acid esters. Excellent enantioselectivities (E = 40 to >500) were achieved for the resolution of N-protected protein and non-protein amino acid esters giving good yields (28-50%) and high enantiomeric excesses (up to >99%) for both enantiomers.