33007-99-7 Usage
Description
6-Bromo-2-phenylquinoline-4-carboxylic acid is an organic compound characterized by its quinoline core, which is substituted with a bromine atom at the 6th position and a phenyl group at the 2nd position. It also features a carboxylic acid functional group at the 4th position. 6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID is known for its potential applications in various chemical and pharmaceutical processes due to its unique structural features.
Uses
Used in Pharmaceutical Industry:
6-Bromo-2-phenylquinoline-4-carboxylic acid is used as a reactant for the preparation of (triazolothiadiazolyl)quinolines. These compounds are of interest in the pharmaceutical industry due to their potential therapeutic properties. The condensation of aminotriazolethiols with quinolinecarboxylates, such as 6-bromo-2-phenylquinoline-4-carboxylic acid, leads to the formation of these bioactive molecules, which can be further explored for their pharmacological applications.
Additionally, due to the structural diversity and functional group versatility of 6-bromo-2-phenylquinoline-4-carboxylic acid, it can be potentially used in the synthesis of other complex organic molecules, which may find applications in various industries such as agrochemicals, dyes, and materials science. However, further research and development are required to fully explore and establish the utility of this compound in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 33007-99-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,0,0 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 33007-99:
(7*3)+(6*3)+(5*0)+(4*0)+(3*7)+(2*9)+(1*9)=87
87 % 10 = 7
So 33007-99-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H10BrNO2/c17-11-6-7-14-12(8-11)13(16(19)20)9-15(18-14)10-4-2-1-3-5-10/h1-9H,(H,19,20)
33007-99-7Relevant articles and documents
Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives
Nicolaie, E,Guengoer, T,Goyard, J,Cure, G,Fouquet, A,et al.
, p. 977 - 984 (2007/10/02)
The onset of diabetic complications may be prevented by the inhibition of aldose reductase.Derivatives of N-(quinolinyl thiocarbonyl) glycine were prepared and their in vitro and ex vivo aldose reductase inhibitory activities were tested on rat lens.The cincophen derivatives were the most potent in vitro with an enzyme inhibition value of 29percent at 10-8 M and 91percent at 10-7 for the N--N-methylglycine compound 10a.This activity was shown to be dependent on the nature of the substituents and seems to be optimal for the acids; esterswerefound to be inactive.No compound have shown ex vivo inhibitory activity.It is concluded that the lack of ex vivo activity is likely due to a poor bioavailability or a bad penetration of the compounds in target tissue (lens). aldose reductase inhibitors / diabetic complications / N-(quinolinyl thiocarbonyl) glycine
