3302-87-2Relevant articles and documents
Synthesis of a new chiral source, (1R,2S)-1-phenylphospholane-2-carboxylic acid, via a key intermediate α-phenylphospholanyllithium borane complex: Configurational stability and X-ray crystal structure of an α- monophosphinoalkyllithium borane complex
Sun, Xiang-Min,Manabe, Kei,Lam, William W.-L.,Shiraishi, Nobuyuki,Kobayashi, Jun,Shiro, Motoo,Utsumi, Hiroaki,Kobayashi, Shu
, p. 361 - 368 (2005)
A synthetic route to enantiomerically pure (1R,2S)-1-phenylphos-pholane-2- carboxylic acid (1), which is a phosphorus analogue of proline, has been established. A key step is the deprotonation-carboxylation of the 1-phenylphospholane borane complex 3 by u
Raney-Ni reduction of phosphine sulfides
Demchuk, Oleg M.,?wierczyńska, Wioletta,Dziuba, Kamil,Frynas, S?awomir,Flis, Anna,Pietrusiewicz, K. Micha?
, p. 64 - 68 (2016/12/24)
A variety of tertiary phosphine sulfides have been reduced by Raney-Ni to give the corresponding phosphineswith high efficiency and undermild conditions. Alkyl, aryl, acyclic, cyclic, aswell as sterically crowded phosphine sulfides are reduced with equal facility. Optically active P-stereogenic phosphine sulfides are reduced stereospecifically with clean retention of configuration at P. Reductions of unsaturated phosphinesulfides is not fully chemoselective and takes place with concomitant partial reduction of the double bond. Clean reduction of the unsaturated phosphine sulfides to the corresponding fully saturated phosphines can be achieved in one step by running the reduction under H2atmosphere (balloon).
METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS
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Page/Page column 33; 34, (2014/09/29)
A method for increasing the rate of phosphine oxide reduction, preferably during a Wittig reaction comprising use of an acid additive is provided. A room temperature catalytic Wittig reaction (CWR) the rate of reduction of the phosphine oxide is increased due to the addition of the acid additive is described. Furthermore, the extension of the CWR to semi-stabilized and non-stabilized ylides has been accomplished by utilization of a masked base and/or ylide-tuning.