33043-26-4Relevant articles and documents
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site
Mellini, Paolo,Itoh, Yukihiro,Elboray, Elghareeb E.,Tsumoto, Hiroki,Li, Ying,Suzuki, Miki,Takahashi, Yukari,Tojo, Toshifumi,Kurohara, Takashi,Miyake, Yuka,Miura, Yuri,Kitao, Yuki,Kotoku, Masayuki,Iida, Tetsuya,Suzuki, Takayoshi
, p. 5844 - 5862 (2019/07/04)
The NAD+-dependent deacetylase SIRT2 represents an attractive target for drug development. Here, we designed and synthesized drug-like SIRT2-selective inhibitors based on an analysis of the putative binding modes of recently reported SIRT2-selective inhibitors and evaluated their SIRT2-inhibitory activity. This led us to develop a more drug-like diketopiperazine structure as a "hydrogen bond (H-bond) hunter" to target the substrate-binding site of SIRT2. Thioamide 53, a conjugate of diketopiperazine and 2-anilinobenzamide which is expected to occupy the "selectivity pocket" of SIRT2, exhibited potent SIRT2-selective inhibition. Inhibition of SIRT2 by 53 was mediated by the formation of a 53-ADP-ribose conjugate, suggesting that 53 is a mechanism-based inhibitor targeting the "selectivity pocket", substrate-binding site, and NAD+-binding site. Furthermore, 53 showed potent antiproliferative activity toward breast cancer cells and promoted neurite outgrowth of Neuro-2a cells. These findings should pave the way for the discovery of novel therapeutic agents for cancer and neurological disorders.
Synthesis and angiotensin converting enzyme inhibitory activity of L-lysyl-N-substituted glycine derivatives
Saito,Matsui,Fukushima,Watanabe,Waga,Kajiwara,Shirota,Iijima,Kitabatake
, p. 1558 - 1561 (2007/10/02)
The synthesis and biological activity of novel L-lysyl-N-substituted glycine derivatives which exhibit in vitro and in vivo angiotensin converting enzyme (ACE) inhibition, are described. Particularly, N-[N(α)-(1-carboxy-3-phenylpropyl)-L-lysyl]-N-(4-pheny
Process for acylation with novel acylating agent
-
, (2008/06/13)
This invention relates to a novel acylation process which comprises using as the acylating agent an o-hydroxy-substituted aromatic oxime ester represented by the general formula (I) STR1 and mixing said acylating agent with an amine substance represented