33142-18-6

Basic information

• Product Name: N-PHENYL-2-AMINOTHIAZOLE
• Synonyms: N-phenyl-1,3-thiazol-2-amine
• CAS NO: 33142-18-6
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.24
• Mol File: 33142-18-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 297.727°C at 760 mmHg
• Flash Point: 133.861°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.678
• CAS DataBase Reference: N-PHENYL-2-AMINOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: N-PHENYL-2-AMINOTHIAZOLE(33142-18-6)
• EPA Substance Registry System: N-PHENYL-2-AMINOTHIAZOLE(33142-18-6)

Safety Data

• Hazardous Substances Data: 33142-18-6(Hazardous Substances Data)

Usage

General Description

N-Phenyl-2-aminothiazole is a chemical compound with the molecular formula C9H8N2S. It is a thiazole derivative containing a phenyl group and an amino group. N-Phenyl-2-aminothiazole is commonly used in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a building block for various organic reactions due to its versatile reactivity. Additionally, it has been studied for its potential therapeutic properties, including its role in treating certain medical conditions. N-Phenyl-2-aminothiazole is a valuable compound in the field of organic chemistry and has a wide range of applications in industry and research.

InChI:InChI=1/C9H8N2S/c1-2-4-8(5-3-1)11-9-10-6-7-12-9/h1-7H,(H,10,11)

Upstream product

• 10140-87-1 1,2-dichloroethyl acetate 
• 103-85-5 monophenylthiourea 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 75-07-0 acetaldehyde 
• 133972-63-1 2-phenylaminothiazole-5-carboxylic acid 
• 7647-01-0 hydrogenchloride 
• 96-50-4 2-thiazolylamine 
• 28899-97-0 triphenylbismuth(V) diacetate 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 3034-53-5 2-bromo-1,3-thiazole 
• 62-53-3 aniline 
• 76510-73-1 C₅H₈ClNOS 
• 3034-52-4 2-chlorothiazole 

Downstream Products

• 116055-40-4 N-phenyl-N-thiazol-2-yl-acetamide 
• 99984-48-2 (3-acetyl-3H-thiazol-2-ylidene)-phenyl-amine 
• 63615-95-2 5-Bromo-2-(N-phenylamino)thiazole 
• 840493-92-7 N-phenyl-N-(thiazol-2-yl)carbamic acid 1,1-dimethylethyl ester 
• 840493-89-2 2,2-dimethyl-N-phenyl-N-(thiazol-2-yl)propanamide 
• 840493-90-5 N-(5-bromothiazol-2-yl)-2,2-dimethyl-N-phenylpropanamide 
• 840493-94-9 N-(5-bromothiazol-2-yl)-N-phenylcarbamic acid 1,1-dimethylethyl ester 
• 63616-01-3 phenyl-((3ar,7at)-3a,5,6,7a-tetrahydro-[1,4]dioxino[2,3-d]thiazol-2-yl)-amine 
• 63616-01-3 phenyl-((3ar,7ac)-3a,5,6,7a-tetrahydro-[1,4]dioxino[2,3-d]thiazol-2-yl)-amine 
• 1290104-92-5 C₂₀H₁₆N₂S₂ 

Relevant articles and documents

PROSTACYCLIN RECEPTOR AGONIST

A compound represented by formula (I) or an isomer or a pharmaceutically acceptable salt thereof. The present invention also relates to an application of the same in preparing a drug for treating a disease related to a PGI2 receptor.

Synthesis, characterization and density functional theory study of some new 2-anilinothiazoles

We report here a comparative theoretical and experimental study of anilinothiazoles. The anilinothiazoles are synthesized by acid catalyzed condensation of N-phenylthioureas and 2-chloro-1,1-dimethoxyethane. Substituted anilines were employed to introduce substitution in 2-anilinothiazoles. The experimental geometric and spectroscopic properties of the anilinothiazoles are compared with the theoretically calculated ones. The model developed here comprises of geometry optimization at B3LYP method of DFT at 6-31+G(d) basis set. The optimized geometric parameters of anilinothiazoles show nice correlations with values obtained from X-ray crystal structure. Differences of up to 0.02 ? in bond length and 1.0° in bond angles are observed except SC2N6 and C7N6C2 where this difference is 1.77°and 6.01°, respectively. The vibrational spectra are calibrated with a common scaling factor of 0.9613 and show nice correlations with the experimental IR spectra. The UV-Vis spectra calculated at 190-450 nm range show 20-25 nm difference from the experimental spectra. The consistent difference may be attributed to the condensed phase nature of anilinothiazoles however the theoretical spectra are for single molecules. In addition HOMO, LUMO and the associated band gaps are also calculated and depicted.

Synthesis of 5-arylated N-arylthiazole-2-amines as potential skeletal muscle cell differentiation promoters

A series of N-arylthiazole-2-amines was prepared and their biological activity for the promotion of skeletal muscle cell differentiation was investigated, a process of significant importance in muscle regeneration. A versatile new synthetic route towards