3319-03-7

Basic information

• Product Name: α-(Dimethylamino)acetophenone
• Synonyms: 2-(N,N-Dimethylamino)acetophenone
• CAS NO: 3319-03-7
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• Mol File: 3319-03-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 244.8°Cat760mmHg
• Flash Point: 83.6°C
• Appearance: /
• Density: 1.012g/cm³
• Vapor Pressure: 0.0298mmHg at 25°C
• Refractive Index: 1.523
• Solubility: DCM, Ethyl Amine
• CAS DataBase Reference: α-(Dimethylamino)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: α-(Dimethylamino)acetophenone(3319-03-7)
• EPA Substance Registry System: α-(Dimethylamino)acetophenone(3319-03-7)

Safety Data

• Hazardous Substances Data: 3319-03-7(Hazardous Substances Data)

Usage

Description

α-(Dimethylamino)acetophenone is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a dimethylamino group attached to an acetophenone molecule.

Uses

Used in Pharmaceutical Industry:
α-(Dimethylamino)acetophenone is used as an intermediate in the synthesis of 1-(Dimethylamino)-2-phenyl-2-butanyl 3,4,5-trimethoxybenzoate (D493076), which is a degradation product of trimebutine maleate and an impurity of trimebutine. Trimebutine is an opioid receptor agonist and an antispasmodic agent, utilized for the treatment of acute and chronic abdominal pain. Its role in the synthesis process is crucial for the development of these medications, contributing to their effectiveness in managing pain and discomfort.

InChI:InChI=1/C10H13NO/c1-11(2)8-10(12)9-6-4-3-5-7-9/h3-7H,8H2,1-2H3

Upstream product

• 926-64-7 N,N-Dimethylamino acetonitrile 
• 13574-14-6 2-(dimethylamino)-N,N-dimethylacetamide 
• 63618-36-0 α-N,N-Dimethylamino-N',N'-diaethylacetamid 
• 2243-35-8 2-acetoxyacetophenone 
• 124-40-3 dimethyl amine 
• 70-11-1 α-bromoacetophenone 
• 73620-29-8 dimethylallylphenacylammonium bromide 
• 78501-12-9 anhydro 
• 51-80-9 bis-(dimethylamino)methane 
• 98-86-2 acetophenone 
• 6912-12-5 dimethylamine hydrobromide 
• 78501-00-5 t-butyldimethyl(phenacyl)ammonium bromide 
• 71-43-2 benzene 

Downstream Products

• 109644-97-5 dimethyl-(2-oxo-2-[2]thienyl-ethyl)-phenacyl-ammonium; chloride 
• 5554-63-2 1-methyl-2-(dimethylamino)-1-phenylethanol 
• 122239-79-6 1,4-bis-[(dimethyl-phenacyl-ammonio)-acetyl]-benzene; dibromide 
• 5612-61-3 1-dimethylamino-2-phenyl-butan-2-ol 
• 106523-30-2 1-dimethylamino-3-methyl-2-phenyl-pentan-2-ol 
• 5612-62-4 2-(dimethylamino)-1,1-diphenylethanol 
• 100-41-4 ethylbenzene 
• 6853-14-1 2-dimethylamino-1-phenylethanol 
• 7397-17-3 phenylglyoxal oxazone 
• 53249-87-9 (Z)-2,3-Bis-dimethylamino-1-phenyl-propenone 
• 34469-09-5 (R)-2-dimethylamino-1-phenyl-ethanol 
• 28608-67-5 Butyl-[2-dimethylamino-1-phenyl-eth-(Z)-ylidene]-amine 
• 28608-68-6 Dimethyl-{2-[(Z)-methylimino]-2-phenyl-ethyl}-amine 
• 76118-19-9 but-2-enyldimethylphenacylammonium bromide 

Relevant articles and documents

Synthesis of 1-organyl-1-(trimethylsiloxy)-2-(dimethylamino)ethenes and new hypervalent silicon compounds based thereon

1-Organyl-1-(trimethylsiloxy)-2-(dimethylamino)ethenes were synthesized for the first time, and their reactions with trichloro(methyl)silane and trifluoro(phenyl)silane afforded silicon bis-chelates, methylbis-[2-(dimethylamino)-1-(organyl)ethenolato-N,O]

Superelectrophilic chemistry of amino-nitriles and related substrates

The superacid-promoted Houben/Hoesch reactions of amino-nitriles and related compounds have been studied. The nitriles form dicationic electrophiles and react with benzene in fair to good yields (12-95%). The intermediate iminium ions may also be reduced to the benzylic amines by NaBH4 or H 2.

Asymmetric synthesis of α-N,N-dialkylamino alcohols by transfer hydrogenation of N,N-dialkylamino ketones

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