331989-76-5

Basic information

• Product Name: 3-(4-BROMOPHENYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE
• CAS NO: 331989-76-5
• Molecular Formula: C₁₅H₁₁BrN₂O₂
• Molecular Weight: 331.16
• Mol File: 331989-76-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-BROMOPHENYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMOPHENYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE(331989-76-5)
• EPA Substance Registry System: 3-(4-BROMOPHENYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE(331989-76-5)

Safety Data

• Hazardous Substances Data: 331989-76-5(Hazardous Substances Data)

Usage

General Description

3-(4-Bromophenyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole is a chemical compound with the molecular formula C15H11BrN2O2. It is a heterocyclic compound containing an oxadiazole ring, as well as bromo and methoxy substituents on phenyl rings. 3-(4-BROMOPHENYL)-5-(4-METHOXYPHENYL)-1,2,4-OXADIAZOLE has potential applications in medicinal chemistry and pharmaceutical research, as it exhibits biological activity that may be useful for developing new drugs. Additionally, it can be used as a building block in the synthesis of other organic compounds. This chemical's unique structure and properties make it a valuable tool for scientific research and drug discovery efforts.

Upstream product

• 68451-79-6 C₁₅H₁₃BrN₂O₃ 
• 201230-82-2 carbon monoxide 
• 19227-14-6 p-bromobenzamidoxime 
• 115298-63-0 phenyl(4-methoxyphenyl)iodonium triflate 
• 19227-14-6 (Z)-4-bromo-N′-hydroxybenzimidamide 
• 100-09-4 4-methoxybenzoic acid 
• 623-00-7 4-bromobenzenecarbonitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 7596-36-3 1-(2-(4-methoxyphenyl)-2-oxoethyl)pyridin-1-ium iodide 

Downstream Products

• 422536-00-3 3-(4-bromophenyl)-5-(4-hydroxyphenyl)-1,2,4-oxadiazole 
• 957470-99-4 5-(4-{[1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1H-1,2,3-triazol-4-yl]methoxy}phenyl)-3-(4-bromophenyl)-1,2,4-oxadiazole 
• 957470-91-6 3-(4-bromophenyl)-5-[4-(prop-2-yn-1-yloxy)phenyl]-1,2,4-oxadiazole 
• 1061240-51-4 C₁₅H₁₁IN₂O₂ 
• 1061240-58-1 3-([125I]-4-iodophenyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Direct synthesis of 3,5-diaryl-1,2,4-oxadiazoles using 1-(2-oxo-2-arylethyl)pyridin-1-iums with benzamidines

An efficient domino protocol for the synthesis of 1,2,4-oxadiazole derivatives from readily available 1-(2-oxo-2-arylethyl)pyridin-1-iums and amidine hydrochlorides was developed. In this practical approach, N-acyl amidine precursors were formed firstly via a simple nucleophilic substitution, without the purification of N-acylamidine intermediates, and the following intramolecularly dehydrative cyclization gave 1,2,4-oxadiazole derivatives in the presence of I2/K2CO3/DMSO, which exhibited excellent functional group tolerance and proceeded under simple experimental conditions.

Development of novel β-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole

In the search for novel probes for the imaging in vivo of β-amyloid plaques in Alzheimer's disease (AD) brain, we have synthesized and evaluated a series of 3,5-diphenyl-1,2,4-oxadiazole (DPOD) derivatives. The affinity for β-amyloid plaques was assessed

CYCLIZATION AND ACID-CATALYZED HYDROLYSIS OF O-BENZOYLBENZAMIDOXIMES

Kinetics of formation of 1,2,4-oxadiazoles from 24 substitution derivatives of O-benzoylbenzamidoxime have been studied in sulphuric acid and aqueous ethanol media.It has been found that this medium requires introduction of the Hammett H0 function instead of the pH scale beginning as low as from 0.1percent solutions of mineral acids.Effects of the acid concentration, ionic strength, and temperature on the reaction rate and on the kinetic isotope effect have been followed.From these dependences and from polar effects of substituents it was concluded that along with the cyclization to 1,2,4-oxadiazoles there proceeds hydrolysis to benzamidoxime and benzoic acid.The reaction is thermodynamically controlled by the acid-base equilibrium of the O-benzylated benzamidoximes.