33209-25-5

Basic information

• Product Name: 1,2-Cyclohexanedicarbonyl dichloride, trans-(+)- (9CI)
• Synonyms: trans-(+)-1,2-Cyclohexanedicarbonyldichloride
• CAS NO: 33209-25-5
• Molecular Formula: C₈H₁₀Cl₂O₂
• Molecular Weight: 209.07
• Product Categories: ACIDHALIDE
• Mol File: 33209-25-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclohexanedicarbonyl dichloride, trans-(+)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanedicarbonyl dichloride, trans-(+)- (9CI)(33209-25-5)
• EPA Substance Registry System: 1,2-Cyclohexanedicarbonyl dichloride, trans-(+)- (9CI)(33209-25-5)

Safety Data

• Hazardous Substances Data: 33209-25-5(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Solubility

Insoluble in water, soluble in organic solvents

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Used in the production of polymers
d. Used in the production of dyes

Reactivity

Highly reactive

Safety precautions

Should be handled with care and proper safety measures due to its high reactivity

Upstream product

• 2305-32-0 trans-1,2-cyclohexanedicarboxylic acid 

Downstream Products

• 115720-23-5 (+/-)-trans-1-cyano-cyclohexane-carboxylic acid-(2) 
• 104722-26-1 trans-1,2-dibenzoylcyclohexane 
• 90682-77-2 (3E,9E)-1,2-Diphenyl-3,10-bis-trimethylsilanyloxy-1,2,5,6,7,8-hexahydro-[1,2]diphosphecine 

Relevant articles and documents

Rational tuning chelate size of bis-oxazoline ligands to improve enantioselectivity in the asymmetric aziridination of chalcones

Chalcones were asymmetrically aziridinated with [N-(p-toluenesulfonyl) imino]phenyliodinane (PhI=NTs) as a nitrene source under catalysis of CuOTf and a series of cyclohexane-linked bis-oxazolines (cHBOXes), which are chelate size rationally tuned bis-oxazolines. The results indicate that highly enantioselective aziridination of chalcones with up to >99% ee have been achieved under catalysis of (S,S)-1,2-bis[(S)-(4-phenyl)oxazolin-2-yl] cyclohexane, which is the most-matched stereoisomer among cyclohexane-linked bis-oxazolines. It was also found that the enantioselectivity is not substituent-dependent with respect to chalcones in the present case, unlike with 1,8-anthracene-linked bis-oxazolines (AnBOXes).