33209-75-5

Basic information

• Product Name: 4-(2-methoxyphenyl)butyric acid
• Synonyms: 4-(2-methoxyphenyl)butyric acid
• CAS NO: 33209-75-5
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Mol File: 33209-75-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 41 °C
• Boiling Point: 160 °C/3 mmHg
• Appearance: /
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-(2-methoxyphenyl)butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-methoxyphenyl)butyric acid(33209-75-5)
• EPA Substance Registry System: 4-(2-methoxyphenyl)butyric acid(33209-75-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 33209-75-5(Hazardous Substances Data)

Usage

Description

4-(2-methoxyphenyl)butyric acid, also known as 2-Methyl-2-(4'-methoxyphenyl)butyric acid, is a chemical compound with the molecular formula C11H14O3. It is a derivative of phenylbutyric acid and is commonly used in the pharmaceutical industry as a chiral building block for the synthesis of various drugs. Its structural similarities to other amino acids make it a valuable compound for drug development and research in the field of medicine.

Uses

Used in Pharmaceutical Industry:
4-(2-methoxyphenyl)butyric acid is used as a chiral building block for the synthesis of various drugs, contributing to the development of new medications with improved efficacy and selectivity.
Used in Treatment of Pulmonary Fibrosis:
4-(2-methoxyphenyl)butyric acid is used as a potential therapeutic agent for pulmonary fibrosis, leveraging its anti-inflammatory and antifibrotic properties to alleviate the symptoms and progression of the disease.
Used in Treatment of Liver Fibrosis:
4-(2-methoxyphenyl)butyric acid is used as a potential therapeutic agent for liver fibrosis, utilizing its anti-inflammatory and antifibrotic properties to mitigate the effects of liver scarring and improve liver function.

Upstream product

• 996-82-7 sodium diethylmalonate 
• 36449-75-9 1-(2-bromoethyl)-2-methoxybenzene 
• 72734-85-1 1-(3-chloropropyl)-2-methoxybenzene 
• 77853-46-4 4-(2-Methoxyphenyl)-butanenitrile 
• 103987-16-2 β-methoxy-γ-oxo-γ-phenylbutanoic acid 
• 93108-08-8 methyl 4-(2'-methoxyphenyl)butanoate 
• 99046-13-6 4-oxo-4-(2-methoxyphenyl)butyric acid methyl ester 
• 108840-41-1 1-(2-methoxy-phenyl)-2-(toluene-4-sulfonyloxy)-ethane 
• 105-53-3 diethyl malonate 
• 33209-76-6 Ethyl 4-(2-Methoxyphenyl)-butanoate 
• 90266-01-6 1-diazo-4-(2'-methoxyphenyl)butan-2-one 
• 93-25-4 2-methoxyphenylacetic acid 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 1011-54-7 2-methoxycinnamic acid 

Downstream Products

• 93108-08-8 methyl 4-(2'-methoxyphenyl)butanoate 
• 33209-76-6 Ethyl 4-(2-Methoxyphenyl)-butanoate 
• 33892-75-0 5-Methoxy-1-tetralone 
• 161053-79-8 4-(2-methoxy-phenyl)-butyryl chloride 
• 22565-26-0 4-(2-Methoxy-cyclohexyl)-butanol-⁽¹⁾ 
• 19142-95-1 Thiosulfuric acid S-{2-[4-(2-methoxy-cyclohexyl)-butylamino]-ethyl} ester 
• 21782-51-4 4-(o-Methoxy-cyclohexyl)-butylbromid 
• 33209-77-7 2-Methyl-5-o-anisyl-2-pentanol 
• 33214-70-9 1,1-dimethyl-5-methoxytetralin 

Relevant articles and documents

A heavy-metal-free desulfonylative Giese-type reaction of benzothiazole sulfones under visible-light conditions

A visible-light-induced desulfonylative Giese-type reaction has been developed. Essential to the success is the employment of Hantzsch ester to activate benzothiazole sulfones without any heavy-metal additives. Not only benzylic benzothiazole sulfones but also alkyl ones were viable substrates and reacted with electron-deficient alkenes and a propiol amide.

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Most of the endogenous free D-serine (about 90%) in the brain is produced by serine racemase (SR). D-Serine in the brain is involved in neurodegenerative disorders and epileptic states as an endogenous co-agonist of the NMDA-type glutamate receptor. Thus, SR inhibitors are expected to be novel therapeutic candidates for the treatment of these disorders. In this study, we solved the crystal structure of wild-type SR, and tried to identify a new inhibitor of SR by in silico screening using the structural information. As a result, we identified two hit compounds by their in vitro evaluations using wild-type SR. Based on the structure of the more potent hit compound 1, we synthesized 15 derivatives and evaluated their inhibitory activities against wild-type SR. Among them, the compound 9C showed relatively high inhibitory potency for wild-type SR. Compound 9C was a more potent inhibitor than compound 24, which was synthesized by our group based upon the structural information of the mutant-type SR.

STUDIES ON OXYGEN HETEROCYCLES PART-1 : ACID CATALYSED AND PHOTOCHEMICAL REACTIONS OF SOME ARYLDIAZOKETONES

Trifluoroacetic acid catalysed reaction of 2-methoxyphenyldiazomethylketone (4a), 2-acetoxyphenyldiazomethylketone (4b) and 3-(2-anisyl)-α-diazo-2-propanone (11) leads to the formation of coumaranone (6) and 3-chromanone (12), while 4-(2-anisyl)-α-diazo-2-butanone (16) affords benzo-1-oxepan-3-one (17) and 5-methoxy-2-tetralone (18) in moderate yield.The photochemical decomposition of the said diazoketones (4a, 11 and 16) gave products depending on the length of the side chain present in the substrates.