332160-96-0

Basic information

• Product Name: 2-{[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide
• Synonyms: 2-{[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide
• CAS NO: 332160-96-0
• Molecular Formula: C18H16ClN3O2S
• Molecular Weight: 373.85654
• Mol File: 332160-96-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-{[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide(332160-96-0)
• EPA Substance Registry System: 2-{[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2,5-dimethylphenyl)acetamide(332160-96-0)

Safety Data

• Hazardous Substances Data: 332160-96-0(Hazardous Substances Data)

Upstream product

• 349120-88-3 2-bromo-N-(2,5-dimethylphenyl)acetamide 
• 23766-27-0 2-mercapto-5-(2-chlorophenyl)-1,3,4-oxadiazole 
• 118-91-2 ortho-chlorobenzoic acid 
• 7335-25-3 ethyl 2-chlorobenzoate 
• 5814-05-1 2-chlorobenzoylhydrazide 
• 95-78-3 2,5-Dimethylaniline 

Relevant articles and documents

Synthesis, characterization and biological activity of some new S-substituted derivatives of 5-(2-chlorophenyl)-1,3,4-oxadiazol-2-thiol

Molecules with multi-functional groups are being synthesized to acquire more potent molecules. Two series of S-substituted derivatives of 5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-thiol (4) were synthesized and also evaluated for their biological activities. The 2-chlorobenzoic acid (1) was stepped up to ethyl 2-chlorobenzoate (2), 2-chlorobenzohydrazide (3) and 5-(2-chlorophenyl)-1,3,4- Oxadiazol-2-thiol (4). The molecule 4 was made to react with N-substituted-2-bromoacetamide, 6a-f, to yield N-substituted-2-((5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-yl)sulfanyl)acetamide, 7a-f. Simultaneously, the compound 4 was converted to 2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2- ylthio)acetohydrazide (9) which on reaction with different aldehydes, 10a-g, resulted N'-substituted- 2-(5-(2-chlorophenyl)-1,3,4-Oxadiazol-2-ylthio)acetohydrazide, 11a-g. The proposed structures of the molecules were supported by spectral analysis and the series 7a-f was found to be better antibacterial agents and lipoxygenase enzyme inhibitors as compared to 11a-g.