333-93-7 Usage
Description
1,4-Diaminobutane dihydrochloride, also known as Putrescine dihydrochloride, is a white powder chemical compound derived from the end product of fatty acid metabolism in dead tissues. It is a volatile diamine with a pungent odor and is synthesized by the decarboxylation of ornithine in the presence of the enzyme ornithine decarboxylase. Molecular docking studies have shown the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), which are present in the olfactory epithelium.
Uses
1. Used in Cell Culture Applications:
1,4-Diaminobutane dihydrochloride is used as a medium component for various cell cultures, including mice ganglia culture, retinal ganglion cell culture, and HCT116 colon carcinoma cells. It serves as an essential nutrient for the growth and maintenance of these cells.
2. Used in Enzyme Assays:
In the field of biochemistry, 1,4-Diaminobutane dihydrochloride is used as a substrate in the ornithine decarboxylase (ODC) assay. This assay is crucial for studying the activity of the enzyme ornithine decarboxylase, which is involved in the synthesis of polyamines, including putrescine.
3. Used in Pharmaceutical Research:
Due to its interaction with trace amine-associated receptors (TAAR6 and TAAR8), 1,4-Diaminobutane dihydrochloride holds potential for pharmaceutical research, particularly in the development of drugs targeting these receptors for various therapeutic applications.
4. Used in Chemical Synthesis:
As a chemical compound, 1,4-Diaminobutane dihydrochloride can be utilized as a starting material or intermediate in the synthesis of various other chemicals and pharmaceuticals, particularly those involving the formation of amines or the modification of existing amine-containing compounds.
Biochem/physiol Actions
Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.
Purification Methods
Crystallise the salt from EtOH/H2O. [Beilstein 4 IV 1284.]
Check Digit Verification of cas no
The CAS Registry Mumber 333-93-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 3 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 333-93:
(5*3)+(4*3)+(3*3)+(2*9)+(1*3)=57
57 % 10 = 7
So 333-93-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H12N2.ClH/c5-3-1-2-4-6;/h1-6H2;1H
333-93-7Relevant articles and documents
Hydrosilane Reduction of Nitriles to Primary Amines by Cobalt-Isocyanide Catalysts
Sanagawa, Atsushi,Nagashima, Hideo
supporting information, p. 287 - 291 (2019/01/10)
Reduction of nitriles to silylated primary amines was achieved by combination of 1,1,3,3-tetramethyldisiloxane (TMDS) as the hydrosilane and a catalytic amount of Co(OPIV)2 (PIV = COtBu) associated with isocyanide ligands. The resulting silylated amines were subjected to acid hydrolysis or treatment with acid chlorides to give the corresponding primary amines or imides in good yields. One-pot synthesis of primary amides to primary amines with hydrosilanes was also achieved by iron-cobalt dual catalyst systems.
Synthesis of poly(galactaramides) from alkylene- and substituted alkylenediammonium galactarates
Kiely, Donald E.,Vishwanathan, Arvind,Jarman, Bevan P.,Manley-Harris, Merilyn
experimental part, p. 348 - 368 (2010/01/16)
Polyhydroxypolyamides (PHPAs) represent a class of synthetic polyamides derived from aldaric acid and diamine monomer units. This paper describes the synthesis of some poly(galactaramides), a class of polyhydroxypolyamides, that employs alkylene and subst
1,4-Diaminobutanes from furans: A new synthetic approach to substituted putrescines
Frydman, Benjamin,Ojea, Maria I.
, p. 4765 - 4768 (2007/10/03)
A novel approach for the synthesis of (hydroxymethyl)- and (aminomethyl)-putrescines starting with furanmethanols and aminomethyl- furanmethanols is reported. The furans were converted to their 2,5-dimethoxy- tetrahydrofuran derivatives and the latter were ring-opened in acid media. The resulting carbonyl derivatives were isolated as their dioximes and the latter were then reduced to the corresponding amino alcohols.
