333780-75-9

Basic information

• Product Name: 2,3-DIFLUORO-6-IODOBENZOIC ACID
• Synonyms: 2,3-DIFLUORO-6-IODOBENZOIC ACID
• CAS NO: 333780-75-9
• Molecular Formula: C₇H₃F₂IO₂
• Molecular Weight: 284
• Mol File: 333780-75-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 298.116°C at 760 mmHg
• Flash Point: 134.096°C
• Appearance: /
• Density: 2.144g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,3-DIFLUORO-6-IODOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIFLUORO-6-IODOBENZOIC ACID(333780-75-9)
• EPA Substance Registry System: 2,3-DIFLUORO-6-IODOBENZOIC ACID(333780-75-9)

Safety Data

• Hazardous Substances Data: 333780-75-9(Hazardous Substances Data)

Usage

General Description

2,3-Difluoro-6-iodobenzoic acid is a chemical compound with the molecular formula C7H3F2IO2. It is a derivative of benzoic acid, with a fluorine atom attached to the 2 and 3 positions, and an iodine atom attached to the 6 position. 2,3-Difluoro-6-iodobenzoic acid is known for its wide range of industrial and pharmaceutical applications, including as a building block in the synthesis of organic compounds and pharmaceuticals. It is commonly used in the development of new materials, as well as in the study of pharmacological properties and drug design. Additionally, it has potential applications in the field of agrochemicals and can be utilized as an intermediate in the production of a variety of other chemicals.

InChI:InChI=1/C7H3F2IO2/c8-3-1-2-4(10)5(6(3)9)7(11)12/h1-2H,(H,11,12)

Upstream product

• 124-38-9 carbon dioxide 
• 64248-58-4 1,2-difluoro-4-iodo-benzene 

Downstream Products

• 935660-92-7 2,3-difluoro-6-iodobenzonitrile 
• 796967-67-4 4-(4-aminophenyl)-7-fluoro-1H-indazol-3-amine 
• 935660-91-6 C₇H₄F₂INO 
• 1262193-17-8 (2,4,6-trimethylbenzene-1,3,5-triyl)tris(methylene) tris(2,3-difluoro-6-iodobenzoate) 

Relevant articles and documents

Syntheses of a radiolabelled CXCR2 antagonist AZD5069 and its major human metabolite

The CXCR2 antagonist AZD5069 has been synthesized in tritium and carbon-14-labelled forms. [3H]AZD5069 was prepared via reductive dehalogenation of an iodinated precursor with tritium gas to provide material with a specific activity of 25.1 Ci/

Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5- methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor

In our continued efforts to search for potent and novel receptor tyrosine kinase (RTK) inhibitors as potential anticancer agents, we discovered, through a structure-based design, that 3-aminoindazole could serve as an efficient hinge-binding template for kinase inhibitors. By incorporating an N,N′-diaryl urea moiety at the C4-position of 3-aminodazole, a series of RTK inhibitors were generated, which potently inhibited the tyrosine kinase activity of the vascular endothelial growth factor receptor and the platelet-derived growth factor receptor families. A number of compounds with potent oral activity were identified by utilizing an estradiol-induced mouse uterine edema model and an HT1080 human fibrosarcoma xenograft tumor model. In particular, compound 17p (ABT-869) was found to possess favorable pharmacokinetic profiles across different species and display significant tumor growth inhibition in multiple preclinical animal models.