334018-24-5

Basic information

• Product Name: (2-Chloro-4-methoxy-phenyl)-methanol
• Synonyms: (2-Chloro-4-methoxy-phenyl)-methanol;BENZENEMETHANOL, 2-CHLORO-4-METHOXY
• CAS NO: 334018-24-5
• Molecular Formula: C₈H₉ClO₂
• Molecular Weight: 172.60886
• Mol File: 334018-24-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-Chloro-4-methoxy-phenyl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloro-4-methoxy-phenyl)-methanol(334018-24-5)
• EPA Substance Registry System: (2-Chloro-4-methoxy-phenyl)-methanol(334018-24-5)

Safety Data

• Hazardous Substances Data: 334018-24-5(Hazardous Substances Data)

Usage

General Description

(2-Chloro-4-methoxy-phenyl)-methanol, also known as 3-Methoxy-4-hydroxybenzophenone or benzyl(2-chloro-4-methoxyphenyl)methanol, is an organic compound belonging to the family of phenyl methanols. It is a white to off-white solid with a molecular formula C14H13ClO2 and a molecular weight of 248.70 g/mol. This chemical is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis and as an additive in the production of fragrances, flavors, and cosmetics. Additionally, it has potential applications in the field of medicinal chemistry and is being studied for its potential pharmacological properties. However, it should be handled with care due to its potential hazards, including skin and eye irritation, and its toxic effects if ingested or inhaled.

Upstream product

• 21971-21-1 2-chloro-4-methoxybenzoic acid 
• 41068-36-4 2-chloro-4-methoxyacetophenone 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 54439-75-7 2-chloro-4-methoxybenzaldehyde 
• 108-43-0 3-monochlorophenol 
• 56962-11-9 2-chloro-4-hydroxybenzaldehyde 

Downstream Products

• 101080-63-1 2-chloro-4-methoxybenzyl chloride 
• 54788-17-9 2-chloro-4-methoxybenzyl bromide 
• 622861-56-7 2-[(E)-2-(2-chloro-4-methoxyphenyl)ethenyl]-5-methoxy-1H-indole 
• 622861-57-8 4-(2-chloro-4-methoxyphenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione 
• 67205-77-0 2-Chlor-4-methoxybenzyldiaethylphosphonat 

Relevant articles and documents

Nickel-Catalyzed Asymmetric Reductive Arylbenzylation of Unactivated Alkenes

Herein, we report a nickel-catalyzed asymmetric two-component reductive dicarbofunctionalization of aryl iodide-tethered unactivated alkenes using benzyl chlorides as the challenging coupling partner. This arylbenzylation reaction enables the efficient synthesis of diverse benzene-fused cyclic compounds bearing a quaternary stereocenter with a high tolerance of sensitive functionalities in highly enantioselective manner. The preliminary mechanistic investigations suggest a radical chain reaction mechanism.

Heterocyclic compounds

The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent(s) etc., X is an amino group optionally having substituent(s), Y1 and Y2 are nitrogen atoms etc., an isomer or solvate thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Aqua(sulfato)platinum(II) Complexes with Variable Substituents in the 2-Phenyl Ring. 1. Synthesis and Antitumor and Estrogenic Properties

Erythro- and threo-configurated aqua(sulfato)platinum(II) complexes with variable substituents in the 2-phenyl ring (2-PtSO4 to 9-PtSO4: H, 4-F, 3-OH, 4-OH, 2,6-F2, 2,6-Cl2, 2-F/4-OH, 2-Cl/4-OH) were synthesized and tested for estrogenic and antitumor activities.The ligands were obtained by a three-step reaction.The stilbenes were reacted with a mixture of IN3 and NaN3 to yield the respective 1,2-diazido-1,2-diphenylethanes.The subsequent reduction with LiAlH4 led to the corresponding 1,2-diphenylethylenediamines.The (sulfato)platinum(II) complexes were synthesized by reaction of Ag2SO4 with the diiodo complexes, which had been obtained by coordination of the diamines with K2PtI4.Two complexes, erythro-8-PtSO4 and erythro-9-PtSO4, possess antitumor and estrogenic effects and are therefore of interest for the therapy of breast cancer.