33430-62-5 Usage
Description
Thymidine-5'-monophosphate disodium salt, also known as Thymidine 5'-monophosphate (TMP), is a nucleoside monophosphate that plays a crucial role in the synthesis of deoxyribonucleic acid (DNA). It is a white amorphous powder and is synthesized de novo from deoxyuridine monophosphate (dUMP) through the catalysis of the enzyme thymidylate synthase.
Uses
Used in Pharmaceutical Industry:
Thymidine-5'-monophosphate disodium salt is used as an intermediate in the synthesis of thymidine diphosphate by thymidylate kinase (TMPK), which is a nucleoside monophosphate kinase. This makes it an essential component in the development of various pharmaceutical products related to DNA synthesis and repair.
Used in Biotechnology and Research:
In the biotechnology and research fields, Thymidine-5'-monophosphate disodium salt serves as a key constituent of DNA, making it indispensable for various molecular biology techniques and genetic research applications. It is often utilized in the synthesis of DNA strands, as well as in the study of DNA replication and repair mechanisms.
Used in Diagnostics:
Thymidine-5'-monophosphate disodium salt is also used in the development of diagnostic tools and tests, particularly those related to DNA analysis and detection. Its role in DNA synthesis makes it a valuable component in the creation of assays and probes for genetic testing and disease diagnosis.
Used in Radiopharmaceuticals:
In the field of radiopharmaceuticals, Thymidine-5'-monophosphate disodium salt can be used as a precursor for the synthesis of radiolabeled compounds, which are essential in medical imaging and diagnostic procedures, such as positron emission tomography (PET) scans.
Overall, Thymidine-5'-monophosphate disodium salt is a versatile compound with applications in various industries, including pharmaceuticals, biotechnology, research, diagnostics, and radiopharmaceuticals, due to its importance in DNA synthesis and its role as a constituent of DNA.
Check Digit Verification of cas no
The CAS Registry Mumber 33430-62-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,3 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 33430-62:
(7*3)+(6*3)+(5*4)+(4*3)+(3*0)+(2*6)+(1*2)=85
85 % 10 = 5
So 33430-62-5 is a valid CAS Registry Number.
33430-62-5Relevant articles and documents
5’-Phosphorylation Increases the Efficacy of Nucleoside Inhibitors of the DNA Repair Enzyme SNM1A
Berney, Mark,Fay, Ellen M.,Manoj, Manav T,McGouran, Joanna F.
supporting information, (2022/01/13)
Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand crosslink repair is therefore a promising strategy for improving the efficacy of cancer treatment. One such target enzyme is SNM1A, a zinc co-ordinating 5’–3’ exonuclease. Previous studies have demonstrated the feasibility of inhibiting SNM1A using modified nucleosides appended with zinc-binding groups. In this work, we sought to develop more effective SNM1A inhibitors by exploiting interactions with the phosphate-binding pocket adjacent to the enzyme's active site, in addition to the catalytic zinc ions. A series of nucleoside derivatives bearing phosphate moieties at the 5’-position, as well as zinc-binding groups at the 3’-position, were prepared and tested in gel-electrophoresis and real-time fluorescence assays. As well as investigating novel zinc-binding groups, we found that incorporation of a 5’-phosphate dramatically increased the potency of the inhibitors.
Bis(2,2,2-trichlor-1,1-dimethylethyl)monochlorophosphat, ein selektives Reagens fuer Phosphorylierung und Schutz der 5'-OH-Gruppe von Nucleosid-Derivaten
Kellner, Herbert A.,Schneiderwind, Ruth G. K.,Eckert, Heiner,Ugi, Ivar K.
, p. 581 - 582 (2007/10/02)
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