334994-41-1Relevant articles and documents
Syntheses of the cylindrospermopsin alkaloids
Looper, Ryan E.,Runnegar, Maria T.C.,Williams, Robert M.
, p. 4549 - 4562 (2007/10/03)
An intramolecular 1,3-dipolar cycloaddition has efficiently constructed the A-ring portions of the cylindrospermopsin alkaloids. A nitro-aldol addition of an elaborated nitroalkane to a pyrimidine aldehyde followed by an intramolecular reductive guanidiny
Construction of the A-ring of cylindrospermopsin via an intramolecular oxazinone-N-oxide dipolar cycloaddition
Looper, Ryan E.,Williams, Robert M.
, p. 769 - 771 (2007/10/03)
The efficient synthesis of an A-ring synthon for the marine hepatatoxin cylindrospermopsin has been achieved. The key step features an intramolecular oxazinone N-oxide/alkene dipolar cycloaddition resulting in the establishment of the three contiguous ste