335349-55-8

Basic information

• Product Name: 1-Benzyl-4-iodo-3,5-dimethyl-1H-pyrazole
• Synonyms: 1-Benzyl-4-iodo-3,5-dimethyl-1H-pyrazole
• CAS NO: 335349-55-8
• Molecular Weight: 312.153
• Mol File: 335349-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Benzyl-4-iodo-3,5-dimethyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-iodo-3,5-dimethyl-1H-pyrazole(335349-55-8)
• EPA Substance Registry System: 1-Benzyl-4-iodo-3,5-dimethyl-1H-pyrazole(335349-55-8)

Safety Data

• Hazardous Substances Data: 335349-55-8(Hazardous Substances Data)

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 2033-45-6 4-iodo-3,5-dimethyl-1H-pyrazole 
• 100-39-0 benzyl bromide 

Downstream Products

• 374756-64-6 2-[3-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-prop-2-ynyloxy]isoindole-1,3-dione 
• 374756-67-9 O-[3-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-prop-2-ynyl]hydroxylamine 
• 374756-61-3 3-(1-Benzyl-3,5-dimethyl-1H-pyrazol-4-yl)-prop-2-yn-1-ol 

Relevant articles and documents

O-pyrazolylpropynyl-hydroxylamines as versatile intermediates in the synthesis of compounds of pharmacological interest

Through an optimised Pd/Cu-catalysed cross-coupling reaction of 4-iodopyrazoles with 2-propyn-1-ol, followed by Mitsunobu transformation with N-hydroxyphthalimide and subsequent hydrazinolysis, O-[(pyrazol-4-yl)-prop-2-ynyl]-hydroxylamines were obtained in good yields. Their usefulness as intermediates in the synthesis of pharmaceuticals is exemplified by the first reported intramolecular cyclization of O-(2-propynyl)-hydroxylamines to yield 4,5-dihydro-isoxazoles.