33560-48-4

Basic information

• Product Name: N1-(3,5-DICHLOROPHENYL)-2-CHLOROACETAMIDE
• Synonyms: 2,3’,5’-trichloro-acetanilid;N-(Chloroacetyl)-3,5-dichloroaniline;2,3',5'-Trichloroacetanilide;N-(3,5-Dichlorophenyl)-2-chloroacetamide;2-chloro-N-(3,5-dichlorophenyl)ethanamide;ACETANILIDE, 2,3',5'-TRICHLORO-;ART-CHEM-BB B015625;2-CHLORO-N-(3,5-DICHLOROPHENYL)ACETAMIDE
• CAS NO: 33560-48-4
• Molecular Formula: C₈H₆Cl₃NO
• Molecular Weight: 238.5
• Mol File: 33560-48-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 140-142
• Boiling Point: 387 °C at 760 mmHg
• Flash Point: 187.8 °C
• Appearance: /
• Density: 1.511 g/cm³
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: N1-(3,5-DICHLOROPHENYL)-2-CHLOROACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N1-(3,5-DICHLOROPHENYL)-2-CHLOROACETAMIDE(33560-48-4)
• EPA Substance Registry System: N1-(3,5-DICHLOROPHENYL)-2-CHLOROACETAMIDE(33560-48-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 33560-48-4(Hazardous Substances Data)

Usage

General Description

N1-(3,5-Dichlorophenyl)-2-chloroacetamide is a chemical compound with the molecular formula C8H6Cl3NO. It is a white crystalline solid that is used as a herbicide and pesticide. It is known for its ability to inhibit the activity of the enzyme acetohydroxyacid synthase, which is essential for the biosynthesis of branched-chain amino acids in plants. This inhibition leads to the death of the plant. The compound is considered toxic and should be handled with caution. It is important to follow safety protocols and regulations when working with N1-(3,5-Dichlorophenyl)-2-chloroacetamide to prevent harm to human health and the environment.

InChI:InChI=1/C8H6Cl3NO/c9-4-8(13)12-7-2-5(10)1-6(11)3-7/h1-3H,4H2,(H,12,13)

Upstream product

• 79-04-9 chloroacetyl chloride 
• 626-43-7 3,5-Dichloroaniline 

Downstream Products

• 104911-89-9 N,N-diethyl-glycine-(3,5-dichloro-anilide) 
• 76809-59-1 N-(3,5-Dichloro-phenyl)-2-iodo-acetamide 
• 113518-55-1 N-(3,5-Dichloro-phenyl)-2-(4-phenyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-acetamide 
• 76809-95-5 2-hydroxyamino-N-(3,5-dichlorophenyl)acetamide hydrochloride 
• 76810-14-5 1-(3,5-Dichloro-phenyl)-4-oxy-1H-pyrazin-2-one 
• 76809-75-1 C₁₅H₁₂Cl₂N₂O₂ 
• 1266715-53-0 (Z)-N-(3,5-dichlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetamide 
• 575499-16-0 N-(3, 5-dichlorophenyl)-2-(4-formylphenoxy)acetamide 
• 1310561-77-3 N-(3,5-dichlorophenyl)-2-(4-((4,6-dioxo-2-thioxotetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)acetamide 
• 1310561-64-8 N-(3,5-dichlorophenyl)-2-(4-((2,4,6-trioxotetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)acetamide 
• 1242606-93-4 C₂₇H₂₅Cl₂N₅O 
• 1334386-53-6 C₁₈H₂₇Cl₂N₃O 
• 1334386-55-8 C₂₀H₂₉Cl₂N₃O 
• 1334386-57-0 C₂₀H₂₉Cl₂N₃O 

Relevant articles and documents

Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors

Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration up to 250 μM. Of note, 2,2′-dithiobis(N-(2-fluorophenyl)acetamide) (d7), 2,2′-dithiobis(N-(3,5-difluorophenyl)acetamide) (d24), and 2,2′-dithiobis(N-(3-fluorophenyl)acetamide) (d8) were here identified as the most active inhibitors with IC50 of 0.074, 0.44, and 0.81 μM, showing 32- to 355-fold higher potency than the positive control acetohydroxamic acid. These disulfides were confirmed to bind urease without covalent modification of the cysteine residue and to inhibit urease reversibly with a mixed inhibition mechanism. They also showed very good anti-Helicobacter pylori activities with d8 showing a comparable potency to the clinical used drug amoxicillin. The impressive in vitro biological profile indicated their immense potential as therapeutic agents to tackle H. pylori caused infections.

PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX) / histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Synthesis and biological evaluation of N-(substituted phenyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides as antimicrobial, antidepressant, and anticonvulsant agents

A new series of N-Aryl-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamides were synthesized by condensation of tricyclic compound 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione with chloro N-phenylacetamides. The tricyclic compound was obtaine