336182-29-7 Usage
Description
4-Bromo-N-isopropylbenzamide, also known as N-(4-bromophenyl)-propan-2-yl benzamide, is a chemical compound with the molecular formula C10H12BrNO. It is an aromatic amide that features a benzene ring with a bromine substitution and a N-isopropyl group attached to the amide nitrogen. 4-Bromo-N-isopropylbenzamide is widely recognized for its role as a building block in organic synthesis and pharmaceutical research, and it holds potential for applications in medicinal chemistry for the development of new drugs.
Uses
Used in Organic Synthesis:
4-Bromo-N-isopropylbenzamide is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-Bromo-N-isopropylbenzamide is utilized as a key intermediate in the development of new drugs. Its properties and reactivity make it suitable for the synthesis of drug candidates with potential therapeutic applications.
Used in Medicinal Chemistry:
4-Bromo-N-isopropylbenzamide is employed in medicinal chemistry for the design and optimization of novel drug molecules. Its structural features can be leveraged to enhance the potency, selectivity, and pharmacokinetic properties of drug candidates, contributing to the advancement of new therapeutic agents.
Overall, 4-Bromo-N-isopropylbenzamide is a versatile and valuable chemical compound with applications across various industries, particularly in organic synthesis, pharmaceutical research, and medicinal chemistry. Its unique structure and properties make it an essential component in the development of new drugs and other chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 336182-29-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,6,1,8 and 2 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 336182-29:
(8*3)+(7*3)+(6*6)+(5*1)+(4*8)+(3*2)+(2*2)+(1*9)=137
137 % 10 = 7
So 336182-29-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12BrNO/c1-7(2)12-10(13)8-3-5-9(11)6-4-8/h3-7H,1-2H3,(H,12,13)
336182-29-7Relevant articles and documents
Hydrogenation of Secondary Amides using Phosphane Oxide and Frustrated Lewis Pair Catalysis
K?ring, Laura,Sitte, Nikolai A.,Bursch, Markus,Grimme, Stefan,Paradies, Jan
supporting information, p. 14179 - 14183 (2021/09/03)
The metal-free catalytic hydrogenation of secondary carboxylic acid amides is developed. The reduction is realized by two new catalytic reactions. First, the amide is converted into the imidoyl chloride by triphosgene (CO(OCCl3)2) using novel phosphorus(V) catalysts. Second, the in situ generated imidoyl chlorides are hydrogenated in high yields by an FLP-catalyst. Mechanistic and quantum mechanical calculations support an autoinduced catalytic cycle for the hydrogenation with chloride acting as unusual Lewis base for FLP-mediated H2-activation.
N-Heterocyclic Carbene-Mediated Microfluidic Oxidative Electrosynthesis of Amides from Aldehydes
Green, Robert A.,Pletcher, Derek,Leach, Stuart G.,Brown, Richard C. D.
supporting information, p. 1198 - 1201 (2016/03/15)
A flow process for N-Heterocyclic Carbene (NHC)-mediated anodic oxidative amidation of aldehydes is described, employing an undivided microfluidic electrolysis cell to oxidize Breslow intermediates. After electrochemical oxidation, the reaction of the intermediate N-acylated thiazolium cation with primary amines is completed by passage through a heating cell to achieve high conversion in a single pass. The flow mixing regimen circumvented the issue of competing imine formation between the aldehyde and amine substrates, which otherwise prevented formation of the desired product. High yields (71-99%), productivities (up to 2.6 g h-1), and current efficiencies (65-91%) were realized for 19 amides.
Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides
Du, Bingnan,Sun, Peipei
, p. 1176 - 1182 (2014/08/18)
The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant, the reaction provided N,N
