33630-99-8 Usage
Description
3-Amino-2-pyridinol, also known as 3-Amino-2-hydroxypyridine, is an organic compound with the molecular formula C5H6N2O. It is a brown to off-white crystalline powder that serves as a crucial building block in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be used in the development of different therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3-Amino-2-pyridinol is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. It plays a vital role in the preparation of benzothiazolyl hydroxyindolinylphenyl ureas, which are potent P2Y1 antagonists. These antagonists have potential applications in the treatment of various diseases, including inflammation and pain.
3-Amino-2-pyridinol is also used in the synthesis of functionalized pyrido[4,3-b][1,4]oxazine and imidazo[1,2-a]pyridine derivatives. These derivatives have potential applications in the development of new drugs with diverse therapeutic properties.
In the chemical synthesis process, 3-amino-2-pyridinol can react with ethyl 2-chloro-3-oxopropanoate to produce imidazo[1,2-a]pyridine derivatives or ethyl pyrido[4,3-b][1,4]oxazine-2-carboxylate, depending on the specific reaction conditions and starting materials used.
Overall, 3-Amino-2-pyridinol is a versatile compound with significant applications in the pharmaceutical industry, particularly in the development of new drugs and therapeutic agents. Its unique chemical properties and reactivity make it an essential component in the synthesis of various bioactive molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 33630-99-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,6,3 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 33630-99:
(7*3)+(6*3)+(5*6)+(4*3)+(3*0)+(2*9)+(1*9)=108
108 % 10 = 8
So 33630-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O/c6-4-2-1-3-7-5(4)8/h1-3H,6H2,(H,7,8)
33630-99-8Relevant articles and documents
Synthesis of naphthyridinone derivatives as potential antimalarials
Carroll,Berrang,Linn
, p. 941 - 946 (1981)
-
Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues
Hwang, Jimin,Strange, Natalie,Phillips, Matthew J.A.,Krause, Alexandra L.,Heywood, Astra,Gamble, Allan B.,Huston, Wilhelmina M.,Tyndall, Joel D.A.
, (2021/07/16)
The obligate intracellular bacterium Chlamydia trachomatis (C. trachomatis) is responsible for the most common bacterial sexually transmitted infection and is the leading cause of preventable blindness, representing a major global health burden. While C.
Synthesis and applications of 3-amino-2-hydroxypyridine
-
Paragraph 0012-0013; 0015; 0019; 0023, (2018/10/11)
The invention discloses synthesis and applications of 3-amino-2-hydroxypyridine. The synthesis steps comprise: (1) dissolving 2-hydroxy-3-nitro-5-bromopyridine in a solvent, stirring, adding the mixture of iron powder and hydrochloric acid, carrying out a reaction for 0.5-1 h, and carrying out post-treatment to obtain 2-hydroxy-3-amino-5-bromopyridine; and (2) dissolving the 2-hydroxy-3-amino-5-bromopyridine obtained in the step (1) in an alkaline solution, adding strontium carbonate, introducing hydrogen into a reaction bottle, carrying out a reaction for a certain time, and carrying out conventional treatment to obtain 3-amino-2-hydroxypyridine. According to the present invention, the production cost is substantially reduced, and the obtained 3-amino-2-hydroxypyridine has the high purityand can be directly used in the next step.
