33667-91-3

Basic information

• Product Name: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%
• Synonyms: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%
• CAS NO: 33667-91-3
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Mol File: 33667-91-3.mol
• Article Data: 36

Chemical Properties

• Melting Point: 71-73 °C(Solv: dichloromethane (75-09-2))
• Boiling Point: 318.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• PKA: 13.17±0.70(Predicted)
• CAS DataBase Reference: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(33667-91-3)
• EPA Substance Registry System: N-(4-Methoxyphenyl)-4-MethylbenzaMide, 97%(33667-91-3)

Safety Data

• Hazardous Substances Data: 33667-91-3(Hazardous Substances Data)

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 104-94-9 4-methoxy-aniline 
• 25569-87-3 benzoic-p-methylbenzoic anhydride 
• 26218-73-5 3,4-bis(4-methylphenyl)-1,2,5-oxadiazole-N-oxide 
• 30669-07-9 4-methoxy-N-[(4-methylphenyl)methylidene]aniline 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 619-55-6 para-methylbenzamide 
• 594815-59-5 (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(bis(3,5-bis(trifluoromethyl)phenyl)phosphine) 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 681446-06-0 N-[(benzotriazol-1-yl)(4-methylphenyl)methylidene]-4-methoxyaniline 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 99-94-5 p-Toluic acid 
• 300382-54-1 (4-methoxy-phenyl)-p-tolyl-methanone oxime 
• 696-62-8 para-iodoanisole 

Downstream Products

• 21011-45-0 4-methyl-N-(4-methoxyphenyl)benzothioamide 
• 84662-51-1 1-(4-Methoxyphenyl)-5-(4-methylphenyl)-1H-tetrazol 
• 681446-06-0 N-[(benzotriazol-1-yl)(4-methylphenyl)methylidene]-4-methoxyaniline 
• 101078-54-0 2-p-Tolyl-benzothiazol-6-ol 
• 101078-51-7 6-methoxy-2-(4-tolyl)-1,3-benzothiazole 
• 101078-57-3 Acetic acid 2-p-tolyl-benzothiazol-6-yl ester 
• 101078-70-0 diethyl 4-(5-hydroxybenzo[d] thiazol-2-yl)benzylphosphonate 
• 101078-67-5 Acetic acid 2-[4-(diethoxy-phosphorylmethyl)-phenyl]-benzothiazol-6-yl ester 
• 84662-52-2 N-(p-anisyl)-4-methylbenzenecarboxyimidoyl chloride 
• 1254368-96-1 4-(4-methoxyphenyl)-3-(4-nitrophenyl)-5-p-tolyl-4H-[1,2,4]triazole 
• 1254368-95-0 4-[4-(4-methoxyphenyl)-5-p-tolyl-4H-[1,2,4]triazol-3-yl]pyridine 
• 24239-12-1 6-methoxy-2-(4-methylphenyl)-1,3-benzoxazole 

Relevant articles and documents

Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles

Matrix presented A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditio

Amide Bond Formation via the Rearrangement of Nitrile Imines Derived from N-2-Nitrophenyl Hydrazonyl Bromides

We report how the rearrangement of highly reactive nitrile imines derived from N-2-nitrophenyl hydrazonyl bromides can be harnessed for the facile construction of amide bonds. This amidation reaction was found to be widely applicable to the synthesis of primary, secondary, and tertiary amides and was used as the key step in the synthesis of the lipid-lowering agent bezafibrate. The orthogonality and functional group tolerance of this approach was exemplified by the N-acylation of unprotected amino acids.

Method for synthesizing amide derivative under catalysis of vanadium

The invention discloses a method for synthesizing an amide derivative under the catalysis of vanadium, which comprises the following step of: by using a nitro aromatic compound and an ester compound as raw materials, a vanadium compound as a catalyst and magnesium chips as a reducing agent, carrying out amidation reaction in an organic solvent to obtain the amide derivative. The method has the advantages that (1) the nitro aromatic compound which is good in stability, low in price and easy to obtain is used as a nitrogen source; (2) the used catalyst is cheap, easy to obtain and low in toxicity; and (3) the method has good substrate applicability, and is suitable for aromatic nitro compounds, fatty esters and aryl esters containing different substituents.

Carbon-Carbon Bond Formation of Trifluoroacetyl Amides with Grignard Reagents via C(O)-CF3 Bond Cleavage

The reaction of trifluoroacetyl amides with Grignard reagent for the substitution of CF3 group with various alkyl or aryl groups is described. A variety of aryl, quinolin-8-yl, and (hetero)alkyl functional groups as well as F, Cl, and Br atoms are well tolerated. These moisture-stable and easily available trifluoroacetyl amides can be conveniently obtained and used as new versatile precursors for isocyanates. The control experiments show that the reaction proceeds via an isocyanate intermediate and/or alkoxide/amide dual anionic intermediate.