33672-82-1

Basic information

• Product Name: Benzamide, N-methyl-N-(4-nitrophenyl)-
• CAS NO: 33672-82-1
• Molecular Formula: C14H12N2O3
• Molecular Weight: 256.261
• Mol File: 33672-82-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzamide, N-methyl-N-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-methyl-N-(4-nitrophenyl)-(33672-82-1)
• EPA Substance Registry System: Benzamide, N-methyl-N-(4-nitrophenyl)-(33672-82-1)

Safety Data

• Hazardous Substances Data: 33672-82-1(Hazardous Substances Data)

Upstream product

• 1934-92-5 N-methyl-N-phenyl-benzamide 
• 3393-96-2 p-nitrobenzanilide 
• 74-88-4 methyl iodide 
• 65-85-0 benzoic acid 
• 100-15-2 N-methyl(p-nitroaniline) 
• 636-98-6 p-nitrobenzene iodide 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 88070-48-8 N-methylbenzamide 
• 121-69-7 N,N-dimethyl-aniline 
• 98-88-4 benzoyl chloride 
• 77-78-1 dimethyl sulfate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 63721-85-7 benzoic acid-(4-amino-N-methyl-anilide) 
• 1382354-41-7 C₂₁H₁₈N₂O₃ 
• 1382353-97-0 N-(4-(2-carbamoylphenylamino)phenyl)-N-methylbenzamide 
• 1382354-37-1 C₂₂H₂₀N₂O₃ 
• 21010-29-7 N-methyl-N-(4-nitrophenyl)thiobenzamide 

Relevant articles and documents

Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core

Upon controlled microwave heating and using cyanuric chloride as a coupling reagent, an efficient amidation procedure for the synthesis of 1,3-dihydro-2H-benzo[d]imidazol-2-one-based agonists of TRPC3/6 ion channels has been developed. Compared to the few conventional protocols, a drastic reduction in processing time from ca. 2 days down to 10 minutes was achieved accompanied by significantly improved product yields. The robustness of the method was confirmed by 18 additional examples including aromatic, aliphatic, and heterocyclic amines and acids. The obtained agonists were screened for biological activity at 1 μM concentration and few structure-activity relations have been established.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Selective inhibitors of human sirtuin 2 (SIRT2), a deacetylase, are candidate therapeutic agents for neurodegenerative diseases such as Parkinson's disease and Huntington's disease as well as potential tools for elucidating the biological functions of SIRT2. On the basis of homology models of SIRT1 and SIRT2, we designed and prepared a series of 2-anilinobenzamide analogues. Enzyme assays using recombinant SIRT1 and SIRT2 revealed that 3'-phenethyloxy-2- anilinobenzamide analogues such as 33a and 33i are potent and selective SIRT2 inhibitors, showing more than 3.5-fold greater SIRT2-inhibitory activity and more than 35-fold greater SIRT2-selectivity compared with AGK2 (3), a previously reported SIRT2-selective inhibitor. Compound 33a also induced a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells, indicating selective inhibition of SIRT2 in the cells. These 3'-phenethyloxy-2-anilinobenzamide derivatives represent an entry into a new class of SIRT2-selective inhibitors.

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.