33687-74-0Relevant articles and documents
Novel synthetic approach to 1α,24(R)-dihydroxyvitamin D3 using an asymmetric nitroaldol reaction
Oshida, Jun-Ichi,Okamoto, Makoto,Azuma, Shizuo,Tanaka, Toshio
, p. 2579 - 2584 (1997)
Rare earth-K-(S)-BINOL complexes were used to catalyze the nitroaldol reaction of the CD-ring 24-aldehyde precursors with 2-nitropropane in a good stereoselective manner. The obtained nitroaldol compound was easily converted into a synthetic intermediate
Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof
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Paragraph 0198; 0199, (2017/10/10)
Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.
Indium-mediated reaction of 1-bromo-1-nitroalkanes with aldehydes: Access to 2-nitroalkan-1-ols
Soengas, Raquel G.,Estevez, Amalia M.
experimental part, p. 5190 - 5196 (2010/11/02)
A novel method for the preparation of 2-nitroalkan-1-ols by an indium-promoted reaction of bromonitromethane with a variety of aldehydes is reported. The reaction was also performed with 2-bromo-2-nitropropanes to afford 2,2-dialkyl-2-nitroalkan-1-ols. The use of chiral sugar-derived aldehydes furnished the corresponding 2-nitroalkan-1-ols with excellent stereoselectivity. The utility of the novel sugar-derived 2,2-dialkyl-2-nitroalkan-1-ols for the preparation of branched iminosugar derivatives was demonstrated by the preparation of a hydroxymethyl branched polyhydroxylated azepane.