3381-56-4

Basic information

• Product Name: 3α-(toluene-4-sulfonyloxy)-cholest-5-ene
• Synonyms: 3α-(toluene-4-sulfonyloxy)-cholest-5-ene
• CAS NO: 3381-56-4
• Molecular Weight: 540.851
• Mol File: 3381-56-4.mol
• Article Data: 89

Chemical Properties

• CAS DataBase Reference: 3α-(toluene-4-sulfonyloxy)-cholest-5-ene(CAS DataBase Reference)
• NIST Chemistry Reference: 3α-(toluene-4-sulfonyloxy)-cholest-5-ene(3381-56-4)
• EPA Substance Registry System: 3α-(toluene-4-sulfonyloxy)-cholest-5-ene(3381-56-4)

Safety Data

• Hazardous Substances Data: 3381-56-4(Hazardous Substances Data)

Upstream product

• 138665-17-5 4-Methyl-benzenesulfinic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 57-88-5 cholesterol 
• 98-59-9 p-toluenesulfonyl chloride 
• 133-59-5 Toluene-2-sulfonyl chloride 
• 2309-32-2 3-acetoxy-cholesta-3,5-diene 
• 3464-61-7 6,β-bromo-4-cholesten-3-one 
• 2243-09-6 5α-cholestane-3,6-dione 
• 570-85-4 5α-cholestane-3β,6β-diol 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 77588-15-9 Cholesteryl-4-methoxybenzolsulfonat 
• 104-15-4 toluene-4-sulfonic acid 
• 1174-92-1 cholesteryl methyl ether 
• 57-88-5 cholesterol 
• 15223-09-3 6β-hydroxy-3β-p-toluenesulfonyloxy-5α-cholestane 

Downstream Products

• 747-90-0 3,5-cholestadiene 
• 79327-32-5 6β-phenylsulfanyl-3α,5α-cyclo-cholestane 
• 2126-93-4 cholest-5-en-3-amine 
• 1433-84-7 3α.5α-cyclo-cholestanyl-(6β)-amine 
• 24116-43-6 5-chloro-3β-(toluene-4-sulfonyloxy)-5α-cholestan-6β-ol 
• 10322-03-9 cholesterol butyl ether 
• 604-35-3 Cholesteryl acetate 
• 465-54-3 3,5-cyclocholesterol 
• 1179-15-3 cholesteryl tert-butyl ether 
• 57-88-5 cholesterol 
• 4351-55-7 cholesteryl formate 
• 1253-90-3 5α-cholestan-3β-yldimethylamine 
• 75010-38-7 cholesteryl tetradecyl ether 
• 66106-91-0 cholesteryl cis-9'-octadecenyl ether 

Relevant articles and documents

Sensitized photooxygenation of cholesterol and pseudo-cholesterol derivatives via singlet oxygen

3-Substituted cholesterols and 7-substituted pseudocholesterols undergo a facile photooxygenation sensitized by 9, 10-dicyanoanthracene (DCA) and lumiflavin (LF) to give similar, oppositely-positioned enol derivatives. Both steroids showed the same reaction pattern associated with the endocyclic 5- and 4-olefin units, respectively. The reaction was proposed to proceed via the ene reaction of singlet oxygen and subsequent rearrangement of the initially formed 5α-hydroperoxides.

-

-

Preparation and application of brain glioma targeting berberine and folic acid modified lipid material

The invention discloses preparation and application of a brain glioma targeting berberine and folic acid modified lipid material, and can be used for preparing lipidosome modified by brain glioma targeting Tween 80 coated berberine and folic acid. The liposome surface is coated with Tween 80 and can pass through the blood-brain barrier effectively through receptor-mediated endocytosis after binding with low density lipoprotein receptors to deliver the drug to the brain. In addition, the liposome uses folic acid and berberine to modify brain glioma targeting and mitochondrial targeting capacity of the liposome, and the long chain of polyethylene glycol is introduced to stabilize the liposome. A new thought and a method can be provided for targeted therapy of glioma, and a wide application prospect is provided. pH MDR. The utility model can provide a new idea and a method for targeted therapy of brain glioma.

GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS

The present invention describes compositions containing cholesterol-linker-glutathione conjugates for targeting the brain by overcoming barrier entry to the CNS through the blood brain barrier (BBB), including micelle and liposome forms of such compositions. In addition, methods for treating subjects by administering such compositions are also disclosed.