33832-98-3

Basic information

• Product Name: o-(hydroxymethyl)benzamide
• Synonyms: o-(hydroxymethyl)benzamide;Benzamide, 2-(hydroxymethyl)- (9CI);2-(Hydroxymethyl)benzamide
• CAS NO: 33832-98-3
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• EINECS: 251-692-8
• Product Categories: AMIDE
• Mol File: 33832-98-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140-150 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 346.1°Cat760mmHg
• Flash Point: 163.1°C
• Appearance: /
• Density: 1.239g/cm³
• Vapor Pressure: 2.23E-05mmHg at 25°C
• Refractive Index: 1.598
• PKA: 14.11±0.10(Predicted)
• CAS DataBase Reference: o-(hydroxymethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: o-(hydroxymethyl)benzamide(33832-98-3)
• EPA Substance Registry System: o-(hydroxymethyl)benzamide(33832-98-3)

Safety Data

• Hazardous Substances Data: 33832-98-3(Hazardous Substances Data)

Usage

General Description

O-(hydroxymethyl)benzamide is a chemical compound with the molecular formula C8H9NO2. It is a derivative of benzamide, with a hydroxymethyl group attached to the ortho position of the benzene ring. o-(hydroxymethyl)benzamide is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block for the synthesis of various bioactive compounds. O-(hydroxymethyl)benzamide has also been studied for its potential pharmacological activities, including its anti-inflammatory and anti-cancer properties. Its functional groups make it a versatile intermediate for the preparation of various organic compounds, making it a valuable chemical in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C8H9NO2/c9-8(11)7-4-2-1-3-6(7)5-10/h1-4,10H,5H2,(H2,9,11)

Upstream product

• 87-41-2 2-benzofuran-1(3H)-one 
• 610-93-5 6-nitrophthalide 

Downstream Products

• 87-41-2 2-benzofuran-1(3H)-one 
• 13213-88-2 1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 
• 4152-84-5 2-(aminomethyl)benzyl alcohol hydrochloride 

Relevant articles and documents

Solid support for the synthesis of 3'-amino oligonucleotides

The present invention discloses novel methods and solid supports for the synthesis of 3′-amino oligonucleotides. The novel supports are based on an unsubstituted or ring-substituted hydroxymethylbenzoyl linker element wherein the hydroxymethyl group is esterified to a solid phase bound carboxylic acid and the carbonyl group is linked to an amino alcohol as an amide. Oligonucleotides are conveniently synthesized on the novel supports with no modifications in the standard phosphoramidite synthesis scheme. The ester function of the support is cleaved under the alkaline deprotection conditions for oligonucleotides to provide a free hydroxymethyl group that aids in the release of the 3′-amino oligonucleotide products with a free amino group through neighbor group participation. The free amino group of the oligonucleotides is available for further conjugation reactions to haptens, reporter groups, surfaces or other small molecules or biomolecules. The methods provided are particularly mild, do not require any modifications in standard protocols for the synthesis and deprotection of oligonucleotides, provide the 3′-amino oligonucleotides free of side products and do not introduce chiral centers to the oligonucleotides.