33898-53-2Relevant articles and documents
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
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Paragraph 001130, (2017/08/01)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Chemistry of aziridinecarboxylic acids; Part 2. Convenient synthesis of 2-aminopropenenitrile
Jahnisch,Weight,Bosies
, p. 1211 - 1212 (2007/10/02)
2-Aminopropenenitrile (4) has been prepared by dehydrochlorination of 2-amino-3-chloropropanenitrile (3) with triethylamine. A simple and efficient synthesis of 2-cyanoaziridine (2) by reaction of 2,3-dibromopropanenitrile (1) with ammonia in methanol in the presence of triethanolamine is described.
Chemistry of α-Aminonitriles. Aziridin-2-carbonitrile, a Source of Racemic O3-Phosphonoserinenitrile and Glycolaldehyde Phosphate
Wagner, Ernst,Xiang, Yi-Bin,Baumann, Karl,Gueck, Juergen,Eschennmoser, Albert
, p. 1391 - 1409 (2007/10/02)
Racemic aziridine-2-carbonitrile (rac-1) in MeCN solution reacts regioselectively (>90percent) with 2 equiv. of TsOH at room temperature to form the hydrotosylate of racemic O3-tosylserinenitrile (rac-2) via a β-ring opening (Scheme 2).A similar regioselective reaction takes place between rac-1 and H3PO4 to produce racemic O3-phosphoserinenitrile (rac-3) which is in turn a source of glycolaldehyde phosphate (=formylmethyl dihydrogenphosphate) under the conditions of a 'retro-Strecker' reaction in aqueous solution (Scheme 6).These experiments document a close structural relationship between the simplest of the sugar phosphates and an α-aminonitrile precursor.