33930-63-1

Basic information

• Product Name: 4-bromo-2-methyl-isoquinolin-1-one
• Synonyms: 4-bromo-2-methyl-isoquinolin-1-one;4-bromo-2-methylisoquinolin-1(2H)-one;4-broMo-2-Methyl-1,2-dihydroisoquinolin-1-one;4-Bromo-2-methyl-2H-isoquinolin-1-one;NSC 218343;4-Bromo-2-methyl-1(2H)-isoquinolinone;4-Bromo-2-methylisoquinolin-1(2H)
• CAS NO: 33930-63-1
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.09
• Mol File: 33930-63-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 129-130 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 345.8°Cat760mmHg
• Flash Point: 162.9°C
• Appearance: /
• Density: 1.592g/cm³
• Vapor Pressure: 6.02E-05mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.97±0.70(Predicted)
• CAS DataBase Reference: 4-bromo-2-methyl-isoquinolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-methyl-isoquinolin-1-one(33930-63-1)
• EPA Substance Registry System: 4-bromo-2-methyl-isoquinolin-1-one(33930-63-1)

Safety Data

• Hazardous Substances Data: 33930-63-1(Hazardous Substances Data)

Usage

General Description

4-bromo-2-methyl-isoquinolin-1-one is a synthetic compound that belongs to the class of chemicals known as isoquinolines, a type of heterocyclic aromatic organic compound. It contains a bromine atom and a methyl group attached to an isoquinoline backbone. The systematic name of this chemical is 4-bromoisochinolin-1(2H)-one, and it comes in a solid state at room temperature. Its applications are predominantly in the area of chemistry research, being used as a reactant in chemical syntheses. The properties of this compound, including its reactivity and toxicity, are largely determined by the presence of the bromine atom and the isoquinoline structure.

InChI:InChI=1/C10H8BrNO/c1-12-6-9(11)7-4-2-3-5-8(7)10(12)13/h2-6H,1H3

Upstream product

• 4594-71-2 N-methylisocarbostyril 
• 3951-95-9 4-bromo-1,2-dihydroisoquinolin-1-one 
• 74-88-4 methyl iodide 
• 1532-97-4 4-bromoisoquinoline 
• 54931-73-6 4-bromo-2-methylisoquinolin-2-ium iodide 
• 491-30-5 1-isoquinolone 

Downstream Products

• 1349798-31-7 C₂₄H₂₈N₂O₂ 

Relevant articles and documents

SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted arylmethyl ureas and heteroarylmethyl-ureas, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient.

An organocatalyst bound α-aminoalkyl radical intermediate for controlled aerobic oxidation of iminium ions

A catalyst bound α-aminoalkyl radical intermediate from iminium is developed to control its formation and reactivity with aerobic oxygen. The influence of the catalyst was demonstrated via the ease of radical intermediate formation and its subsequent reactivity, including the first catalyst-controlled enantioselective aerobic oxidation with a chiral phosphite catalyst.

Iridium(III)-Catalyzed Regiocontrolled Direct Amidation of Isoquinolones and Pyridones

Iridium(III)-catalyzed highly regiocontrolled C3/C8 amidation of isoquinolones and C6 amidation of 2-pyridones has been successfully accomplished with various azides. The optimized method is operationally simple with a broad substrate scope. The protocol has been found to be scalable. (Figure presented.).