33930-64-2

Basic information

• Product Name: 2-benzyl-4-bromoisoquinolin-1(2H)-one
• Synonyms: 2-benzyl-4-bromoisoquinolin-1(2H)-one
• CAS NO: 33930-64-2
• Molecular Weight: 314.181
• Mol File: 33930-64-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-benzyl-4-bromoisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-4-bromoisoquinolin-1(2H)-one(33930-64-2)
• EPA Substance Registry System: 2-benzyl-4-bromoisoquinolin-1(2H)-one(33930-64-2)

Safety Data

• Hazardous Substances Data: 33930-64-2(Hazardous Substances Data)

Upstream product

• 13605-95-3 N-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 34784-02-6 3-bromoisoquinoline 
• 100-39-0 benzyl bromide 
• 23277-04-5 2-benzylisoquinolin-2-ium bromide 
• 59168-21-7 2-benzyl-1-(2H)-isoquinoline ketone 
• 1532-97-4 4-bromoisoquinoline 
• 108-88-3 toluene 
• 119-65-3 isoquinoline 
• 3951-95-9 4-bromo-1,2-dihydroisoquinolin-1-one 
• 491-30-5 1-isoquinolone 

Downstream Products

• 1558050-02-4 2-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-one 
• 1616401-70-7 2-benzyl-4-(4-hydroxy-3-methoxyphenyl)isoquinolin-1(2H)-one 
• 1616401-69-4 2-benzyl-4-(3,4,5-trimethoxyphenyl)isoquinolin-1(2H)-one 
• 1616401-67-2 2-benzyl-4-(3,4-dimethoxyphenyl)isoquinolin-1(2H)-one 
• 1616401-68-3 2-benzyl-4-(3,5-dimethylisoxazol-4-yl)isoquinolin-1(2H)-one 
• 1616401-73-0 2-benzyl-4-((3,4,5-trimethoxyphenyl)amino)isoquinolin-1(2H)-one 

Relevant articles and documents

Oxidation of the inert sp3C-H bonds of tetrahydroisoquinolines through C-H activation relay (CHAR): construction of functionalized isoquinolin-1-ones

A TBN/O2-initiated oxidation of the relatively inert 3,4-C-H bonds of THIQs was accomplished, in which the existence of an α-phosphoric ester group is crucial to enable dioxygen trapping and intramolecular HAT (C-H activation relay,CHAR), reali

Visible-Light-Induced Controlled Oxidation of N-Substituted 1,2,3,4-Tetrahydroisoquinolines for the Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones and Isoquinolin-1(2H)-ones

A visible light-rose bengal-TBHP mediated, controlled oxidation of N-substituted 1,2,3,4-tetrahydroisoquinolines is developed for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones and isoquinolin-1(2H)-ones. The present method feature's a broad substrate scope, good functional group tolerances, and the products were prepared in good to excellent yields. The developed methodology further demonstrated in the synthesis of isoindolo[2,1-b] isoquinolin-5(7H)-one (topoisomerase-I inhibitor). (Figure presented.).

Copper-Mediated Oxidative Functionalization of C(sp3)-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

A copper-mediated oxidative functionalization of C(sp3)-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.