339553-22-9

Basic information

• Product Name: 2-amino-5-methyl-N-phenylbenzamide
• Synonyms: 2-amino-5-methyl-N-phenylbenzamide
• CAS NO: 339553-22-9
• Molecular Weight: 226.278
• Mol File: 339553-22-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-amino-5-methyl-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-methyl-N-phenylbenzamide(339553-22-9)
• EPA Substance Registry System: 2-amino-5-methyl-N-phenylbenzamide(339553-22-9)

Safety Data

• Hazardous Substances Data: 339553-22-9(Hazardous Substances Data)

Upstream product

• 608-05-9 5-methyl-indole-2,3-dione 
• 62-53-3 aniline 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 38818-49-4 5-methyl-2-nitrobenzoyl chloride 
• 3113-72-2 5-methyl-2-nitrobenzoic acid 
• 4692-99-3 6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione 

Downstream Products

• 1454775-15-5 6-methyl-2,3-diphenylquinazolin-4(3H)-one 
• 1593583-15-3 6-methyl-3-phenylquinazolin-4(3H)-one 
• 1429192-33-5 C₂₀H₁₈N₂OS 

Relevant articles and documents

Visible-light-induced denitrogenative phosphorylation of benzotriazinones: A metal- And additive-free method for accessing: Ortho -phosphorylated benzamide derivatives

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B2pin2 instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Copper-catalyzed radical methylation/C-H amination/oxidation cascade for the synthesis of quinazolinones

A copper-catalyzed radical methylation/sp3 C-H amination/oxidation reaction for the facile synthesis of quinazolinone was developed. In this cascade reaction, dicumyl peroxide acts not only as a useful oxidant but also as an efficient methyl source. Notably, a methyl radical, generated from peroxide, was confirmed by electron paramagnetic resonance for the first time.

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors

Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution of chlorine or bromine for fluorine on the aniline ring led to the discovery of subnanomolar factor Xa inhibitors. Positions on the anthranilic acid ring that can accommodate further substitution were also identified.