33994-09-1

Basic information

• Product Name: 1-Propanone, 3-bromo-1-(4-methylphenyl)-
• Synonyms: 3-bromo-1-p-tolyl-propan-1-one;3-Brom-1-p-tolyl-propan-1-on;3-Brom-1-p-tolyl-propanon
• CAS NO: 33994-09-1
• Molecular Formula: C10H11BrO
• Molecular Weight: 227.101
• Mol File: 33994-09-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 303.1±25.0 °C(Predicted)
• Density: 1.360±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Propanone, 3-bromo-1-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-bromo-1-(4-methylphenyl)-(33994-09-1)
• EPA Substance Registry System: 1-Propanone, 3-bromo-1-(4-methylphenyl)-(33994-09-1)

Safety Data

• Hazardous Substances Data: 33994-09-1(Hazardous Substances Data)

Usage

Description

1-Propanone, 3-bromo-1-(4-methylphenyl)-, also known as 3-Bromo-1-(p-tolyl)propan-1-one, is an organic compound that belongs to the class of halogenated ketones. It is characterized by the presence of a bromine atom and a methyl group attached to a propyl ketone structure. 1-Propanone, 3-bromo-1-(4-methylphenyl)is known for its reactivity and is often used as a building block in the synthesis of various organic molecules.

Uses

1-Propanone, 3-bromo-1-(4-methylphenyl)is used as a reactant in the stereoselective preparation of medium-sized carbocycles and heterocycles. Its unique structure allows for the formation of complex molecular frameworks with controlled stereochemistry, which is crucial in the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
1-Propanone, 3-bromo-1-(4-methylphenyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and structural diversity make it a valuable building block for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, 1-Propanone, 3-bromo-1-(4-methylphenyl)is employed as a starting material for the synthesis of novel pesticides and herbicides. Its unique properties enable the creation of molecules with enhanced biological activity and selectivity, leading to more effective and environmentally friendly products.
Used in Specialty Chemicals Industry:
1-Propanone, 3-bromo-1-(4-methylphenyl)is also utilized in the synthesis of specialty chemicals, such as fragrances, dyes, and additives. Its versatility and reactivity contribute to the development of innovative products with unique properties and applications.

Upstream product

• 5337-93-9 4'-methylpropiophenone 
• 92821-88-0 2-bromo-4'-methylpropiophenone 
• 7623-16-7 3-bromopropionyl bromide 
• 108-88-3 toluene 
• 15486-96-1 3-Bromopropionyl chloride 

Downstream Products

• 55581-67-4 3-(4'-methylphenyl)isoxazoline 
• 1453810-83-7 C₁₅H₁₈O₅ 
• 1453810-95-1 dimethyl 2-(4-methylbenzoyl)cyclopropane-1,1-dicarboxylate 
• 1479828-43-7 C₁₀H₁₁N₃O 
• 79509-56-1 11-Ethyl-9-p-tolyl-8,11-dihydro-7H-6b,10,11,12-tetraaza-naphtho[2,1-a]azulene 
• 79509-55-0 1-H-3-p-tolyl-4,5-dihydronaphtho<1,2-d>imidazo<3,2-c>-1,2,4-triazepine 
• 79509-57-2 2-chloro-3-(β-p-methylbenzoylethyl)naphtho<1,2-d>imidazole 
• 19832-78-1 1-(4-methylphenyl)prop-2-en-1-one 
• 33994-14-8 Brom-3-methyl-4-phenyl-1-propanol-1 

Relevant articles and documents

Transformation of arenes into 3-arylpyrazoles and 3-arylisoxazolines with β-bromopropionyl chloride, hydrazine, and hydroxylamine

Successive treatment of arenes with β-bromopropionyl chloride and AlCl3, followed by the reactions with hydrazines and Na2CO3, and then with MnO2 gave the corresponding 3-arylpyrazoles in one pot in good to moderate yields. The same successive treatment of arenes with β-bromopropionyl chloride and AlCl3, followed by the reactions with hydroxylamine and KF gave the corresponding 3-arylisoxazolines in one pot in good to moderate yields.

A gold-catalyzed 1,2-acyloxy migration/intramolecular cyclopropanation/ring enlargement cascade: Syntheses of medium-sized heterocycles

The synthesis of medium-sized heterocycles possessing a trans double bond is still a challenge. Herein, gold(I)-catalyzed 1,2-acyloxy migration/intramolecular cyclopropanation/ring enlargement cascade reaction of furans has been developed, providing highly efficient access to ten- and eleven-membered heterocycles with a broad substrate scope under mild reaction conditions. The reaction outcome features high chemoselectivity at the C5-position of furan. Moreover, a trans-double bond was embodied in the medium ring system.

Azido carbonyl compounds as DNA cleaving agents

Irradiation of azido carbonyl compounds using UV light (≥310 nm) produced triplet alkyl nitrenes and aroyl radicals, which resulted in efficient cleavage of single strand DNA at pH 7.0. DNA cleaving ability of azido carbonyl compounds was found to be dependent on its concentration and substituents on its aromatic ring. Further, newly synthesized naphthalene based azido carbonyl compounds showed DNA cleavage ability at longer wavelength of UV light (≥350 nm) and also binding studies revealed that they bind to ct-DNA by weak intercalation mode.