340-05-6

Basic information

• Product Name: 1-PHENYL-2,2,2-TRIFLUOROETHANOL
• Synonyms: (±)α-(trifluoromethyl)benzylalcohol;(R,S)-2,2,2-Trifluoro-1-phenyl-ethanol;1-Phenyl-2,2,2-trifluorethanol;Benzenemethanol,α-(trifluoromethyl)-,(±)-;α-(Trifluoromethyl)benzylalcohol;(+/-)-ALPHA-(TRIFLUOROMETHYL)BENZYLALCOHOL;ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL;2,2,2-TRIFLUORO-1-PHENYLETHANOL
• CAS NO: 340-05-6
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.14
• EINECS: 206-429-1
• Product Categories: Benzene series
• Mol File: 340-05-6.mol
• Article Data: 212

Chemical Properties

• Melting Point: 74.3-75.2 °C
• Boiling Point: 64-65 °C5 mm Hg(lit.)
• Flash Point: 184 °F
• Appearance: /liquid
• Density: 1.297 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.462
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.91±0.10(Predicted)
• BRN: 3197623
• CAS DataBase Reference: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(340-05-6)
• EPA Substance Registry System: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(340-05-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• HazardClass: IRRITANT
• Hazardous Substances Data: 340-05-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C8H7F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7,12H

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 17750-24-2 1-propyl-1,4-dihydronicotinamide 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 287-92-3 Cyclopentane 
• 79048-93-4 5-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 91999-49-4 6-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 91999-48-3 2-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 13502-54-0 1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 124898-12-0 trimethyl[(2,2,2-trifluoro-1-phenylethoxy)]silane 
• 75-46-7 trifluoromethan 
• 99838-02-5 tetraoctylammonium (2-pyrrolidonide) 
• 100-52-7 benzaldehyde 
• 75-63-8 Bromotrifluoromethane 
• 2314-97-8 iodotrifluoromethane 

Downstream Products

• 573-78-4 phthalic acid mono-(2,2,2-trifluoro-1-phenyl-ethyl ester) 
• 384-65-6 1-chloro-2,2,2-trifluoroethylbenzene 
• 434-42-4 1,1,1-trifluoro-2-bromo-2-phenylethane 
• 17659-27-7 1-benzoyloxy-1-phenyl-2,2,2-trifluoroethane 
• 125888-88-2 Phosphorochloridic acid 2,2,2-trifluoro-ethyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 100664-05-9 bis(2,2,2-trifluoroethyl) (α-trifluoromethylbenzyl) phosphate 
• 84877-46-3 2,2,2-trifluoro-1-phenylethyl trifluoromethanesulfonate 
• 93524-65-3 2-(2',5'-difluorophenyl)-1,1,1-trifluoro-2-phenylethane 
• 125888-91-7 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 100664-09-3 Phosphoric acid bis-(2,2,3,3,4,4,4-heptafluoro-butyl) ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 40121-55-9 1-phenyl-2,2,2-trifluoroethyl α-methoxy-α-(trifluoromethyl)phenylacetate 
• 128816-79-5 (2,2,2-trifluoroethyl)(2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl)(α-trifluoromethylbenzyl) phosphate 
• 135311-72-7 (S)-Cyano-fluoro-phenyl-acetic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 135311-72-7 1-phenyl-2,2,2-trifluoroethyl α-cyano-α-fluorophenylacetate 

Relevant articles and documents

Synthesis, Reactivity and Structural Properties of Trifluoromethylphosphoranides

Phosphoranides are interesting hypervalent species which serve as model compounds for intermediates or transition states in nucleophilic substitution reactions at trivalent phosphorus substrates. Herein, the syntheses and properties of stable trifluoromet

Trifluoromethyl reagent as well as synthesis method and application thereof

The invention discloses a trifluoromethyl reagent as well as a synthesis method and application thereof, wherein the structural formula of the trifluoromethyl reagent is as shown in formula I in the specification. According to the invention, diphenyl trifluoromethylphosphine and iodomethane are used as raw materials, and are heated in an organic solvent to carry out an addition reaction to prepare the trifluoromethylation reagent. The method is simple and convenient in process, high in yield and capable of realizing 10-gram-level large-scale preparation; more importantly, the trifluoromethylation reagent can be used as a free radical and a nucleophilic reagent to be applied to free radical addition reaction and simple nucleophilic addition reaction to prepare different types of trifluoromethylation products, so that the method has important application value.

Synthesis of Unsymmetric Triarylmethanes Bearing CF 3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of δ-Trifluo romethyl Substituted para -Quinone Methides

Pre-synthesized δ-CF 3-δ-aryl-disubstituted para -quinone methides bearing δ-substituents were identified as isolable and storable substrates for 1,6-arylation reactions. A broad range of electron-rich arenes and heteroarenes participated in the arylation process, furnishing a wide array of unsymmetrical CF 3-substituted triarylmethanes in high efficiency. The mild and expeditious protocol exhibited broad scopes of both arene and para -quinone methide components.