3400-41-7

Basic information

• Product Name: CyclopentanecarboxaMide, N-phenyl-
• Synonyms: CyclopentanecarboxaMide, N-phenyl-
• CAS NO: 3400-41-7
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.2536
• Mol File: 3400-41-7.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: CyclopentanecarboxaMide, N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: CyclopentanecarboxaMide, N-phenyl-(3400-41-7)
• EPA Substance Registry System: CyclopentanecarboxaMide, N-phenyl-(3400-41-7)

Safety Data

• Hazardous Substances Data: 3400-41-7(Hazardous Substances Data)

Usage

General Description

Cyclopentanecarboxamide, N-phenyl- is a chemical compound with the molecular formula C12H15NO. It is an amide derivative with a cyclopentane ring and a phenyl group attached to the nitrogen atom. CyclopentanecarboxaMide, N-phenyl- has potential pharmacological properties and is used in medicinal chemistry research for the development of new drugs. It is also used as an intermediate in the synthesis of other organic compounds. However, it is important to handle this chemical with care as it may have hazardous effects on human health and the environment.

Upstream product

• 103-71-9 phenyl isocyanate 
• 33240-34-5 cyclopentylmagnesium bromide 
• 4524-93-0 Cyclopentanecarboxylic acid chloride 
• 62-53-3 aniline 
• 17933-34-5 3-phenyl-3,4,5,6,7,7a-hexahydro-benzo[1,2,3]triazol-3a-ol 
• 936-52-7 1-(N-morpholino)cyclopent-1-ene 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 103-72-0 phenyl isothiocyanate 
• 142-29-0 cyclopentene 
• 3242-56-6 2-diazocyclohexanone 
• 3400-47-3 1,2-diaza-spiro[2.5]oct-1-en-4-one 
• 128535-00-2 3-Cyclopentencarbonsaeureanilid 
• 201230-82-2 carbon monoxide 
• 287-92-3 Cyclopentane 

Relevant articles and documents

Beckmann rearrangement of ketoxime catalyzed by N-methyl-imidazolium hydrosulfate

Beckmann rearrangement of ketoxime catalyzed by acidic ionic liquid-N-methyl-imidazolium hydrosulfate was studied. Rearrangement of benzophenone oxime gave the desirable product with 45% yield at 90 ?C. When co-catalyst P2O5 was added, the yield could be improved to 91%. The catalyst could be reused three cycles with the same efficiency. Finally, reactions of other ketoximes were also investigated.

OH-catalyzed amidation of azides and aldehydes: An efficient route to amides

A [bmIm]OH-catalyzed amidation of azides and aldehydes is reported. This reaction is easily handled and proceeds under mild conditions. The overall transformation involves azide-enolate cycloaddition, which subsequently undergoes rearrangement to give amides. Importantly, the employment of ionic liquid makes this transformation green and practical.

Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water

A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N′-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.