340042-28-6Relevant articles and documents
Synthesis of novel 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines as potential protein kinase inhibitors
Susnik, Marko P.,Schnuerch, Michael,Mihovilovic, Marko D.,Mereiter, Kurt,Stanetty, Peter
experimental part, p. 423 - 430 (2010/05/01)
A short and efficient sequence for the synthesis of a series of 4-(2-amino-5-thiazolyl)-pyrimidine-2-amines was developed. 1-Phenyl-2-(6- pyrimidinyl)-ethanones, obtained via Weinreb's methodology, were used in a Hantzsch thiazole cyclization reaction, followed by introduction of the aniline moieties via nucleophilic substitution.
Imidazopyrimidines, potent inhibitors of p38 MAP kinase
Rupert, Kenneth C.,Henry, James R.,Dodd, John H.,Wadsworth, Scott A.,Cavender, Druie E.,Olini, Gilbert C.,Fahmy, Bohumila,Siekierka, John J.
, p. 347 - 350 (2007/10/03)
The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-α and IL-1β. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-α in vivo.
