34239-04-8

Basic information

• Product Name: 1-BENZYL-4-TRIFLUOROMETHYLBENZENE
• Synonyms: 1-BENZYL-4-TRIFLUOROMETHYLBENZENE;3-Benzylbenzotrifluoride;1-(4-(Trifluoromethyl)benzyl)benzene
• CAS NO: 34239-04-8
• Molecular Formula: C₁₄H₁₁F₃
• Molecular Weight: 236.23
• Mol File: 34239-04-8.mol
• Article Data: 68

Chemical Properties

• Appearance: /
• Density: 1.167
• Refractive Index: 1.51
• CAS DataBase Reference: 1-BENZYL-4-TRIFLUOROMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-4-TRIFLUOROMETHYLBENZENE(34239-04-8)
• EPA Substance Registry System: 1-BENZYL-4-TRIFLUOROMETHYLBENZENE(34239-04-8)

Safety Data

• Hazardous Substances Data: 34239-04-8(Hazardous Substances Data)

Usage

Description

1-BENZYL-4-TRIFLUOROMETHYLBENZENE, with the molecular formula C15H11F3, is a benzene derivative characterized by the presence of a benzyl group and a trifluoromethyl group attached to the benzene ring. 1-BENZYL-4-TRIFLUOROMETHYLBENZENE is recognized for its aromatic properties and serves as a crucial building block in organic synthesis and pharmaceutical research for the creation of other organic compounds. Its unique chemical structure and properties also render it a valuable asset in the field of medicinal chemistry, particularly for research and development within the pharmaceutical industry.

Uses

Used in Organic Synthesis:
1-BENZYL-4-TRIFLUOROMETHYLBENZENE is used as a key intermediate in organic synthesis for the production of a variety of aromatic chemicals. Its structural features make it a versatile component in the creation of complex organic molecules.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, 1-BENZYL-4-TRIFLUOROMETHYLBENZENE is utilized as a building block for the synthesis of pharmaceutical compounds. Its unique properties allow it to contribute to the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry:
1-BENZYL-4-TRIFLUOROMETHYLBENZENE is employed in medicinal chemistry for its potential to be incorporated into novel drug molecules. Its distinct chemical structure offers opportunities for the design of innovative pharmaceutical agents with improved efficacy and selectivity.
Used in the Production of Aromatic Chemicals:
1-BENZYL-4-TRIFLUOROMETHYLBENZENE is also used in the manufacturing process of various aromatic chemicals, leveraging its aromatic nature to contribute to the scent, flavor, or other chemical properties of the end products in industries such as perfumery, flavoring, and specialty chemicals.

Upstream product

• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 395-23-3 phenyl(4-(trifluoromethyl)phenyl)methanol 
• 787-49-5 1-(chloro(phenyl)methyl)-4-(trifluoromethyl)-benzene 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 98-80-6 phenylboronic acid 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 100-44-7 benzyl chloride 
• 13326-10-8 benzyl methyl carbonate 
• 270921-40-9 [(4-trifluoromethyl)phenyl]methyl methyl carbonate 
• 884-90-2 benzyl diethyl phosphate 
• 100-39-0 benzyl bromide 
• 89751-95-1 para-(trifluoromethyl)benzyl acetate 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 100-52-7 benzaldehyde 

Downstream Products

• 620-86-0 4-Benzylbenzoic acid 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 1326231-76-8 1-(phenyl(4-(trifluoromethyl)phenyl)methyl)-1H-benzo[d]imidazole 
• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 1425513-34-3 2,3-diphenyl-6-(phenyl(4-(trifluoromethyl)phenyl)methyl)-1-(4-(trifluoromethyl)phenyl)-1H-indene 
• 1425513-36-5 2,3-bis(4-chlorophenyl)-6-(phenyl(4-(trifluoromethyl)phenyl)methyl)-1-(4-(trifluoromethyl)phenyl)-1H-indene 

Relevant articles and documents

Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides

The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.

Nitrenium Salts in Lewis Acid Catalysis

Molecular compounds featuring nitrogen atoms are typically regarded as Lewis bases and are extensively employed as donor ligands in coordination chemistry or as nucleophiles in organic chemistry. By contrast, electrophilic nitrogen-containing compounds are much rarer. Nitrenium cations are a new family of nitrogen-based Lewis acids, the reactivity of which remains largely unexplored. In this work, nitrenium ions are explored as catalysts in five organic transformations. These reactions are the first examples of Lewis acid catalysis employing nitrogen as the site of substrate activation. Moreover, these compounds are readily accessed from commercially available reagents and exhibit remarkable stability toward moisture, allowing for benchtop transformations without the need to pretreat solvents.

Palladium-Catalyzed Hiyama Coupling of Benzylic Ammonium Salts via C-N Bond Cleavage

The first palladium-catalyzed Hiyama cross-coupling of arylsilanes with benzyltrimethylammonium salts is reported. The reaction proceeds smoothly to facilitate C(sp2)-C(sp3) bond formation via cleavage of the C-N bond and provides a useful approach to various diarylmethanes with a broad substrate scope and excellent functional group tolerance in good to excellent yields.