343-94-2 Usage
Description
Tryptamine hydrochloride is an organic compound with the chemical formula C10H13N2·HCl. It is a derivative of tryptamine, which is an indole alkaloid naturally found in the plant kingdom and some animals. Tryptamine hydrochloride is a beige to light orange powder and is known for its fluorescence property, which has been studied in reverse micelles solution made with benzylhexadecyldimethylammonium chloride (BHDC) in benzene.
Uses
Used in Pharmaceutical Industry:
Tryptamine hydrochloride is used as a reactant for the preparation of various pharmaceutical compounds, including:
1. Tryptamine derivatives as inhibitors against hepatitis B virus: These derivatives help in the development of treatments for hepatitis B by inhibiting the virus's replication and spread.
2. Carbamoyl epipodophyllotoxins as potential antitumor agents: These compounds have shown potential in treating various types of cancer due to their ability to inhibit cell division and proliferation in cancer cells.
3. Anthranilic acid derivatives as CCK receptor antagonists: These derivatives are used in the development of drugs targeting cholecystokinin (CCK) receptors, which play a role in various physiological processes, including digestion and pain transmission.
4. Brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors: These compounds inhibit the enzyme indoleamine 2,3-dioxygenase, which is involved in the breakdown of tryptophan. Inhibition of this enzyme has potential therapeutic applications in various diseases, including neurodegenerative disorders and cancer.
5. Antispasmodic agents: Tryptamine hydrochloride and its derivatives can be used in the development of antispasmodic drugs, which help in relieving muscle spasms and pain.
6. β-carbolinium cations as new antimalarial agents: These cations, derived from tryptamine hydrochloride, have shown potential as new antimalarial agents, offering an alternative to traditional treatments for malaria.
Purification Methods
Crystallise the salt from EtOH/water or EtOH/Et2O. See previous entry for UV. [Beilstein 22 II 347, 22 III/IV 4319, 22/10 V 46.]
Check Digit Verification of cas no
The CAS Registry Mumber 343-94-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 343-94:
(5*3)+(4*4)+(3*3)+(2*9)+(1*4)=62
62 % 10 = 2
So 343-94-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2/p+1
343-94-2Relevant articles and documents
Kinetics and mechanism of the condensation of pyridoxal hydrochloride with L-tryptophan and D-tryptophan, and the chemical transformation of their products
Pishchugin,Tuleberdiev
, p. 1851 - 1854 (2017)
The kinetics and mechanism of interaction between pyridoxal and L-tryptophan, D-tryptophan, and their derivatives are studied. It is found that condensation reactions proceed via three kinetically distinguishable stages: (1) the rapid intraplanar addition of the NH2 groups of the amino acids to pyridoxal with the formation of amino alcohols; (2) the rotational isomerism of amino alcohol fragments with their subsequent dehydration and the formation of a Schiff base with a specific configuration; (3) the abstraction of α-hydrogen in the product of condensation of pyridoxal with L-tryptophan, or the abstraction of СО2 in the product of condensation of pyridoxal with D-tryptophan with the formation of quinoid structures, hydrolysis of which results in the preparation of pyridoxamine and keto acid or pyridoxal and tryptamine, respectively. Schiff bases resistant to further chemical transformations are formed in the reaction with tryptophan methyl ester.
Indolamide compound capable of selectively inhibiting gastric cancer cells
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Paragraph 0024; 0025, (2018/10/19)
The invention discloses an indolamide compound capable of selectively inhibiting gastric cancer cells. The compound is capable of inhibiting the gastric cancer cells, particularly MGC-803 (human gastric cancer cells) cell strains, therefore the compound can be used as medicines for the selectively treatment of gastric cancer and has better developing prospect.
Cyclometalated beta-carboline ruthenium complex and preparation method and application thereof
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Page/Page column 7, (2017/07/23)
The invention relates to the technical field of antitumor drugs and concretely discloses a cyclometalated beta-carboline ruthenium complex and a preparation method and application thereof. The ruthenium complex takes 1-phenyl-9H-pyrido[3,4-b] indole as a main ligand, and takes 2,2-bipyridyl or 4,4-dimethyl-2,2 bipyridyl as an ancillary ligand. The ruthenium complex has a very excellent anti-tumor effect and has more excellent activity against liver cancer, breast cancer, lung cancer and cervical cancer cell lines than cis-platinum and similar polypyridine carboline ruthenium complexes.
