34404-32-5 Usage
Description
H-D-LYS(Z)-OH, also known as N6-[(Phenylmethoxy)carbonyl]-D-lysine, is a protected amino acid with a white powder form. It is characterized by its chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
H-D-LYS(Z)-OH is used as a building block for the synthesis of pharmaceutical compounds, specifically Chrysobactin [N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine], which acts as a siderophore. This application is due to its unique chemical structure that allows for the creation of complex molecules with potential therapeutic properties.
Used in Chemical Synthesis:
H-D-LYS(Z)-OH is used as a protected amino acid in chemical synthesis processes. Its protective group (Z) ensures that the amino acid's functional groups are shielded during reactions, preventing unwanted side reactions and allowing for selective modifications. This application is important for the development of new compounds with specific properties and functions.
Used in Research and Development:
H-D-LYS(Z)-OH is used as a research tool in the field of biochemistry and molecular biology. Its unique structure and properties make it a valuable compound for studying protein synthesis, enzyme mechanisms, and other biological processes. This application is crucial for advancing our understanding of biological systems and developing new therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 34404-32-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,4,0 and 4 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 34404-32:
(7*3)+(6*4)+(5*4)+(4*0)+(3*4)+(2*3)+(1*2)=85
85 % 10 = 5
So 34404-32-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m1/s1
34404-32-5Relevant articles and documents
Novel aminopeptidase n inhibitors with improved antitumor activities
Wang, Qiang,Shi, Qiao,Huang, Lu
, p. 98 - 106 (2015/12/01)
A series of aminopeptidase N (APN) inhibitors were designed and synthesized. Enzyme inhibitory, docking and antiproliferative studies were performed to evaluate the derived molecules. Molecule D15, with IC50 values of 10.9 μM, showed the best performance in the APN enzymatic inhibition assay. The binding pattern of molecule D9 and D15 in the active site of APN was predicted by docking studies. Hydrophobic and H-bond interactions were discovered to make key roles in the ligand-receptor bindings. Compared with the previous C7, several molecules such as D9, D14 and D15, exhibited significantly improved activities in inhibiting the growth of HL-60, ES-2, A549 and PLC cell lines.
Synthesis of Unnatural Amino Acids
Acosta, C. Kirk,Bahr, Martin L.,Burdett, James E.,Cessac, James W.,Martinez, Rudy A.,et al.
, p. 914 - 934 (2007/10/02)
This communication presents efficient synthetic procedures for the D and L isomers of Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyllysine dicyclohexylamine salt (Nα-Boc-Nε-Z-Ilys DCHA salt), the D and L isomers of Nα-tert-butyloxycarbonyl-Nεnicotinoyllysine (Nα-Boc-Niclys), β-(3-quinolyl)-D,L-alanine (3-Quinal), and the resolution into the D and L isomers of 3-Quinal.