344411-67-2

Basic information

• Product Name: 2-(2,6-Dichlorophenoxy)propanamide
• Synonyms: 2-(2,6-dichlorophenoxy)propanamide;Propanamide,2-(2,6-dichlorophenoxy)-
• CAS NO: 344411-67-2
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.08
• Mol File: 344411-67-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.364
• Refractive Index: 1.56
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2,6-Dichlorophenoxy)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-Dichlorophenoxy)propanamide(344411-67-2)
• EPA Substance Registry System: 2-(2,6-Dichlorophenoxy)propanamide(344411-67-2)

Safety Data

• Hazardous Substances Data: 344411-67-2(Hazardous Substances Data)

Usage

Uses

2-(2,6-Dichlorophenoxy)-propanamide is an intermediate in the preparation of lofexidine.

InChI:InChI=1/C9H9Cl2NO2/c1-5(9(12)13)14-8-6(10)3-2-4-7(8)11/h2-5H,1H3,(H2,12,13)

Upstream product

• 588678-04-0 C₁₀H₁₀Cl₂O₃ 

Relevant articles and documents

Rac- and R-(+)-[4,4′,5,5′-2H4]-2- (1′-[2″,6″-dichlorophenoxy]-ethyl)-Δ2- imidazoline (lofexidine)

The synthesis of the d4-forms of rac- and R-lofexidine was accomplished. Two methods are described; one method is a two-step synthesis of rac-d4-lofexidine from 2-chloropropionitrile, the second method is a three-step preparation of R-d4-lofexidine in absolute enantiomeric purity from S-methyl lactate. The commercial availability of R-methyl lactate makes this latter enantioselective synthesis applicable also to the synthesis of S-d4- lofexidine. These procedures also conserve the utilization of the relatively expensive [1,1′,2,2′-2H 4]ethylene diamine precursor. The availability of S- and R-d 4-lofexidines will enable pharmacokinetic studies to be carried out to determine if differential in vivo metabolism of the two enantiomers of lofexidine occurs. Copyright