344743-70-0Relevant articles and documents
Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents
Ohkanda, Junko,Buckner, Frederick S.,Lockman, Jeffrey W.,Yokoyama, Kohei,Carrico, Dora,Eastman, Richard,De Luca-Fradley, Kate,Davies, Wendy,Croft, Simon L.,Van Voorhis, Wesley C.,Gelb, Michael H.,Sebti, Sa?d M.,Hamilton, Andrew D.
, p. 432 - 445 (2007/10/03)
On the basis of the structure of the CVIM tetrapeptide substrate of mammalian protein farnesyltransferase, a series of imidazole-containing peptidomimetics was designed and synthesized, and their inhibition activity against Trypanosoma brucei protein farn