345-40-4

Basic information

• Product Name: 1-PHENYL-2,2,3,3,3-PENTAFLUORO-1-PROPANOL
• Synonyms: 2,2,3,3,3-PENTAFLUORO-1-PHENYL-1-PROPANOL;1-PHENYL-2,2,3,3,3-PENTAFLUORO-1-PROPANOL;2,2,3,3,3-PENTAFLUORO-1-PHENYLPROPAN-1-OL;2,2,3,3,3-PENTAFLUORO-1-PHENYLPROPANE-1-OL
• CAS NO: 345-40-4
• Molecular Formula: C₉H₇F₅O
• Molecular Weight: 226.14
• Mol File: 345-40-4.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 74°C/4mm
• Appearance: /
• CAS DataBase Reference: 1-PHENYL-2,2,3,3,3-PENTAFLUORO-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2,2,3,3,3-PENTAFLUORO-1-PROPANOL(345-40-4)
• EPA Substance Registry System: 1-PHENYL-2,2,3,3,3-PENTAFLUORO-1-PROPANOL(345-40-4)

Safety Data

• Hazardous Substances Data: 345-40-4(Hazardous Substances Data)

Usage

Class

Organofluorine compounds

Structure

Phenyl ring and five fluorine atoms attached to a propanol moiety

Usage

Solvent in chemical reactions and processes, reagent in organic synthesis, forms stable and selective complexes with metal ions for use in analytical chemistry and separation techniques, synthesis of drugs in pharmaceutical industry, and intermediate in production of agrochemicals

Safety

Potentially hazardous, requires careful handling and appropriate safety measures

Upstream product

• 422-06-0 2,2,3,3,3-Pentafluoro-propionaldehyde 
• 394-52-5 pentafluoroethyl phenyl ketone 
• 354-64-3 Pentafluoroethyl iodide 
• 100-52-7 benzaldehyde 
• 124898-13-1 trimethyl(pentafluoroethyl)silane 
• 91935-83-0 (Pentafluoroethyl)lithium 
• 378-75-6 perfluoropropionic acid methyl ester 
• 591-51-5 phenyllithium 
• 354-33-6 1,1,1,2,2-pentafluoroethane 
• 865-47-4 potassium tert-butylate 
• 426-65-3 ethyl Pentafluoropropionate 
• 867212-85-9 C₉H₉F₁₅NPSi 
• 14856-93-0 pentafluoroethyl phenyl sulfone 

Downstream Products

• 131510-37-7 1,2,2,3,3,3-hexafluoro-1-phenyl-propane 
• 78693-68-2 Toluene-4-sulfonic acid 2,2,3,3,3-pentafluoro-1-phenyl-propyl ester 
• 884855-23-6 1-chloro-1-phenyl-2,2,3,3,3-pentafluoropropane 
• 41500-48-5 (E)-1-phenyl-1,2,3,3,3-pentafluoro-1-propene 
• 78693-66-0 2,2,3,3,3-pentafluoro-1-phenylpropane 
• 41424-70-8 (Z)-1-phenyl-1,2,3,3,3-pentafluoro-1-propene 
• 394-52-5 pentafluoroethyl phenyl ketone 

Relevant articles and documents

Pentafluoroethyl group containing production of alcohols, organic semiconductor material and intermediate compound of the enzyme activity inhibitor

[A] a pharmaceutical, agrochemical, a pentafluoroethyl group containing alcohol compound useful as a method for producing polymeric functional materials, as well as, organic semiconductor material and enzyme activity inhibitor of the intermediate compound

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

A simple protocol to overcome the explosive pentafluoroethylation of carbonyl compounds by HFC-125 is described. The use of potassium (K) bases with triglyme or tetraglyme as a solvent safely yields the pentafluoroethylation products in good to high yield

On Pentakis(pentafluoroethyl)stannate, [Sn(C2F5)5]?, and the Gas-Free Generation of Pentafluoroethyllithium, LiC2F5

Pentafluoroethyllithium, LiC2F5, has been established as an efficient and versatile reagent for the transfer of the pentafluoroethyl unit to a number of electrophiles. Here, the stability of this species up to ?40 °C is of advantage, particularly in comparison to its smaller congener LiCF3. The usual production of LiC2F5, however, from gaseous HC2F5 or IC2F5 and strong bases requires specially designed apparatuses, which severely impeded its value as a laboratory reagent. In this contribution we communicate an alternative gas-free and highly efficient protocol for the synthesis of LiC2F5 from the already commercialized stannate salt [PPh4][Sn(C2F5)5]. The [Sn(C2F5)5]? anion represents not only the first example of a structurally characterized hypervalent pentaalkylstannate but also serves as a precursor for the synthesis of the homoleptic tetrakis(pentafluoroethyl)stannane, Sn(C2F5)4. The reaction of the latter with n-butyllithium provides an insight into the mechanism of LiC2F5 generation.