345310-98-7

Basic information

• Product Name: Piperazinone, 1-(2-pyridinyl)- (9CI)
• Synonyms: Piperazinone, 1-(2-pyridinyl)- (9CI);Piperazinone, 1-(2-pyridinyl);Piperazinone, 1-(2-pyridinyl) 345310-98-7, Piperazinone, 1-(2-pyrimidinyl) 59637-59-1;1-Pyridin-2-yl-piperazin-2-one dihydrochloride;1-(pyridin-2-yl)piperazin-2-one hydrochloride;1-pyridin-2-yl-piperazin-2-one 2hcl;1-(Pyridin-2-yl)
• CAS NO: 345310-98-7
• Molecular Formula: C9H11N3O
• Molecular Weight: 177.20314
• Product Categories: PIPERIDINE
• Mol File: 345310-98-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 432.539 °C at 760 mmHg
• Flash Point: 215.392 °C
• Appearance: /
• Density: 1.202 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.15±0.20(Predicted)
• CAS DataBase Reference: Piperazinone, 1-(2-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazinone, 1-(2-pyridinyl)- (9CI)(345310-98-7)
• EPA Substance Registry System: Piperazinone, 1-(2-pyridinyl)- (9CI)(345310-98-7)

Safety Data

• Hazardous Substances Data: 345310-98-7(Hazardous Substances Data)

Usage

General Description

Piperazinone, 1-(2-pyridinyl)- (9CI) is a chemical compound that belongs to the class of piperazinones, which are cyclic organic compounds containing a piperazine ring. It is also known as 1-(2-pyridyl)piperazin-2-one. Piperazinone, 1-(2-pyridinyl)- (9CI) is used in the pharmaceutical industry as a building block for the synthesis of various drugs. It has been studied for its potential therapeutic uses, including as an antipsychotic and antipsychotic agent. Additionally, piperazinone, 1-(2-pyridinyl)- (9CI) has been investigated for its potential role in the treatment of central nervous system disorders and as an inhibitor of certain enzymes.

InChI:InChI=1/C9H11N3O/c13-9-7-10-5-6-12(9)8-3-1-2-4-11-8/h1-4,10H,5-7H2

Upstream product

• 374795-58-1 4-phenylmethyl-1-(2-pyridinyl)piperazin-2-one 
• 345310-96-5 2-(2-hydroxyethylamino)-N-pyridin-2-yl-acetamide 
• 998-40-3 tributylphosphine 
• 870-50-8 di-tert-butyl (E)-azodicarboxylate 
• 109-04-6 2-bromo-pyridine 
• 1279815-59-6 1,1-dimethylethyl 4-(2-pyridinyl)-3-oxo-1-piperazinecarboxylate 

Relevant articles and documents

Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

A series of β-amino amide containing substituted piperazine-2-one derivatives was synthesized and evaluated as inhibitors of dipeptidyl pepdidase-4 (DPP-4) for the treatment of type 2 diabetes. As results of intensive SAR study of the series, (R)-4-[(R)-3-amino-4-(2,4,5-trifluorophenyl)- butanoyl]-3-(t-butoxymethyl)-piperazin-2-one (DA-1229) displayed potent DPP-4 inhibition pattern in several animal models, was selected for clinical development.

Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition

The present invention provides a compound of formula (I) in which R1 is generally hydrogen or CF3, R2 is generally hydrogen, W is a cyclic amine, a heterocycle or a group L-Y-X where L-Y is a linking portion and X is generally an aromatic or non-aromatic heterocycle, alkyl or alkylcarbonyl and Z is generally a heterocycle such as 5-methylisoxazol-3-yl, and pharmaceutically acceptable salts thereof for enhancing cognition in conditions such as Alzheimer's Disease, pharmaceutical compositions comprising them, their use for manufacturing medicaments and methods of treatment using them.