34540-22-2

Basic information

• Product Name: Madecassoside
• Synonyms: MADECASSOIDE;MADECASSOSIDE;O-6-Deoxy-alpha-L-mannopyranosyl-(1.4)-O-beta-D-glucopyranosyl-(1.6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate;O-6-deoxy-alpha-L-mannopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranosyl (2alpha,3beta,4alpha,6beta)-2,3,6,23-tetrahydroxyurs-12-en-28-oate;MADECASSOSIDE(P);MADECASSOSIDE hplc;MADECASSOSIDE WITH HPLC;Asiaticoside A
• CAS NO: 34540-22-2
• Molecular Formula: C48H78O20
• Molecular Weight: 975.12
• EINECS: 252-076-1
• Product Categories: Saponins;The group of Asiaticoside;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 34540-22-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 220-223 °C
• Boiling Point: 1043.554 °C at 760 mmHg
• Flash Point: 295.795 °C
• Appearance: white to off-white/
• Density: 1.473 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble1mg/mL, clear, colorless
• PKA: 12.50±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Madecassoside(CAS DataBase Reference)
• NIST Chemistry Reference: Madecassoside(34540-22-2)
• EPA Substance Registry System: Madecassoside(34540-22-2)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YU9555000
• Hazardous Substances Data: 34540-22-2(Hazardous Substances Data)

Usage

Description

Madecassoside is a triterpenoid saponin that is a trisaccharide derivative of madecassic acid. It is found in the tropical Asian plant Centella asiatica and is known for its anti-inflammatory, wound healing, and antioxidant activities. Madecassoside has been shown to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity. It is a white powder in its chemical form.

Uses

Madecassoside is used as an antioxidant and anti-inflammatory agent for protecting against cognitive impairment. Its antioxidant and anti-inflammatory properties make it a valuable compound in the field of healthcare and medicine.
Used in Healthcare Industry:
Madecassoside is used as a therapeutic agent for its anti-inflammatory, wound healing, and antioxidant activities. It is particularly useful in the treatment of various inflammatory conditions and in promoting wound healing.
Used in Pharmaceutical Industry:
Madecassoside is used as a pharmaceutical compound due to its ability to suppress LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity. This makes it a potential candidate for the development of new drugs targeting inflammatory and immune-related disorders.
Used in Cosmetics Industry:
Madecassoside's anti-inflammatory and antioxidant properties also make it a valuable ingredient in the cosmetics industry, where it can be used in skincare products to promote skin health and reduce signs of inflammation and oxidative stress.

InChI:InChI=1/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3