346-47-4

Basic information

• Product Name: Benzoic acid, 2-[(4-fluorophenyl)methyl]-
• CAS NO: 346-47-4
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.239
• Mol File: 346-47-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(4-fluorophenyl)methyl]-(346-47-4)
• EPA Substance Registry System: Benzoic acid, 2-[(4-fluorophenyl)methyl]-(346-47-4)

Safety Data

• Hazardous Substances Data: 346-47-4(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 462-06-6 fluorobenzene 
• 85-44-9 phthalic anhydride 
• 7649-92-5 2-(4-fluorobenzoyl)benzoic acid 

Downstream Products

• 361212-76-2 [2-(4-fluoro-benzyl)-phenyl]-methanol 
• 569657-05-2 2-(4-fluorobenzyl)-N-methoxybenzamide 
• 1580-52-5 3-(4-fluorophenyl)isobenzofuran-1(3H)-one 
• 601472-84-8 2-(4-Fluoro-benzyl)-benzoyl chloride 
• 632340-64-8 2-[4'-fluoro(bromobenzyl)]benzoic acid 

Relevant articles and documents

PROCESS FOR THE PRODUCTION OF [2- (4-FLUORO-BENZYL) -PHENYL] -ACETIC ACID

The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis (2- 15 methoxyethoxy) aluminate (Red-Al) to the corresponding alcohol ; d) chlorinat ing the alcohol obtained in step c) ; e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2) : f1) reacting the product obtained in step d) with sodium cyanide ; f2) hydro lysing the product obtained in step f1). The present invention provides a process for the production of [2-(4-fluoro-benzyl)- phenyl]-acetic acid which is suitable for industrial scale reactors (e.g. which is cleaner and more efficient). Also, [2-(4-fluoro-benzyl)-phenyl]-acetic acid is obtained as a crystalline material with a purity > 95%.

An alternative method for the synthesis of γ-lactones by using cesium fluoride-celite/acetonitrile combination

A variety of 2-(1-bromoalkyl) benzoic acids 4 undergo intramolecular nucleophilic substitution reaction when treated with a CsF-Celite as solid base in acetonitrile under reflux condition to give the corresponding cyclized phthalides in moderate to very good yield. These 2-(1-bromoalkyl) benzoic acids 4 are formed by the α-bromination of 2-alkylbenzoic acids 3 using N-bromosuccinimide and a catalytic amount of α,α′ -azoisobutyronitrile in carbon tetrachloride under reflux.

Imidazo heterocyclic compounds

A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.