3463-03-4

Basic information

• Product Name: 3-(methylsulfanyl)benzenol
• Synonyms: 3-(methylsulfanyl)benzenol;3-(methylsulfanyl)phenol
• CAS NO: 3463-03-4
• Molecular Formula: C₇H₈OS
• Molecular Weight: 140.21
• Mol File: 3463-03-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 105-108°/2mm
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 9.47±0.10(Predicted)
• CAS DataBase Reference: 3-(methylsulfanyl)benzenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(methylsulfanyl)benzenol(3463-03-4)
• EPA Substance Registry System: 3-(methylsulfanyl)benzenol(3463-03-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3463-03-4(Hazardous Substances Data)

Usage

Description

3-(Methylsulfanyl)benzenol, also known as 3-(methylthio)phenol, is an organic compound with the chemical formula C7H8OS. It is a colorless to pale yellow liquid with a strong, unpleasant odor. The molecule consists of a benzene ring with a hydroxyl group at the 3rd position and a methylsulfanyl group attached to the same carbon. 3-(methylsulfanyl)benzenol is known for its versatile chemical properties and potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
3-(Methylsulfanyl)benzenol is used as an intermediate compound for the synthesis of formimidamidine derivatives, which are known for their potential use against phytopathogenic microorganisms. These derivatives can be employed as active ingredients in the development of new drugs or treatments targeting plant diseases caused by harmful microorganisms.
Used in Chemical Synthesis:
In the field of organic chemistry, 3-(methylsulfanyl)benzenol serves as a valuable building block for the synthesis of various organic compounds. Its unique structure allows for further functionalization and modification, making it a useful starting material for the development of new molecules with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
3-(Methylsulfanyl)benzenol is also utilized in research and development laboratories for the study of its chemical properties and reactivity. Understanding the behavior of this compound can lead to the discovery of new synthetic routes and the development of novel compounds with specific applications in various fields.

Upstream product

• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 
• 1783-81-9 3-methylmercaptoaniline 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 108-47-4 2,4-lutidine 
• 624-92-0 Dimethyldisulphide 
• 591-20-8 3-Bromophenol 
• 12775-96-1 copper 
• 33733-73-2 3-bromo-1-(methylthio)benzene 
• 111762-35-7 (3-(methylthio)phenyl)magnesium bromide 
• 40248-84-8 3-mercaptophenol 
• 74-88-4 methyl iodide 

Downstream Products

• 861076-84-8 2,4-dibromo-5-methylsulfanyl-phenol 
• 103262-80-2 1-acetoxy-3-methylsulfanyl-benzene 
• 17067-42-4 methanesulfonic acid-(3-methylsulfanyl-phenyl ester) 
• 57556-25-9 (3-hydroxy-phenyl)-dimethyl sulfonium ; iodide 
• 106590-65-2 3,5-dinitro-benzoic acid-(3-methylsulfanyl-phenyl ester) 
• 36089-74-4 C₁₃H₁₁NO₃S 
• 67127-67-7 2-hydroxy-4-(methylthio)benzoic acid 
• 15105-62-1 3-hydroxyphenyl methyl sulfoxide 
• 95420-73-8 2-hydroxy-4-(methylthio)benzoic acid methyl ester 
• 95420-74-9 4-(methylthio)-2-n-propoxybenzoic acid methyl ester 
• 95420-75-0 4-(methylthio)-2-n-propoxybenzoic acid 
• 89075-29-6 2-(4-Methylsulfanyl-2-propoxy-phenyl)-3H-imidazo[4,5-c]pyridine 
• 89075-36-5 2-(4-Methanesulfinyl-2-propoxy-phenyl)-3H-imidazo[4,5-c]pyridine 
• 103262-86-8 3-(methylsulfonyl)phenyl acetate 

Relevant articles and documents

Synthesis of novel EP4 antagonists and their use in cancer and inflammation

The present invention relates to a compound capable of effectively antagonizing EP4, which is a compound represented by formula I, or a tautomer, a stereoisomer, a hydrate, a solvate, a pharmaceutically-acceptable salt or a prodrug of the compound represented by formula I. R1 is selected from -CH3, -CHF2, and -CF3; R2 is selected from C2-C6 alkyl, C3-C6 cycloalkyl, halogenated C2-C6 alkyl, and halogenated C3-C6 cycloalkyl; R3 is selected from hydrogen, halogen, C1-C2 alkyl, and fluorinated C1-C2 alkyl; R4 is selected from hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, halogenated C1-C6 alkyl, and halogenated C1-C6 alkoxy.

ADDITIVE FOR IMPARTING ULTRAVIOLET ABSORBENCY AND/OR HIGH REFRACTIVE INDEX TO MATRIX, AND RESIN MEMBER USING SAME

Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

Synthetic strategies to 2′-hydroxy-4′- methylsulfonylacetophenone, a key compound for the preparation of flavonoid derivatives

Different strategies for the synthesis of 2′-hydroxy-4′- methylsulfonylacetophenone are reported in the present paper. This compound is considered as a key synthon for the synthesis of new flavonoid derivatives designed as potential cyclooxygenase-2 inhibitors. The retrosynthetic approach via 3′-methylsulfonylacetophenone, which included three synthetic pathways, did not allow us to obtain the expected compound. However, a synthesis from 3-mercaptophenol led to the desired acetophenone in three steps: thiophenol methylation, Friedel-Crafts acetylation and oxidation of the sulphide to the corresponding sulfone. The desired compound, 2′-hydroxy-4′- methylsulfonylacetophenone, will be used as a synthon for the preparation of novel flavonoid derivatives, such as 2′-hydroxychalcones, flavanones, flavones, and flavonols.