3469-00-9

Basic information

• Product Name: METHYL DIPHENYLACETATE
• Synonyms: METHYL DIPHENYLACETATE;LABOTEST-BB LT00160162;DIPHENYLACETIC ACID METHYL ESTER;RARECHEM AL BF 0122;Acetic acid, diphenyl-, methyl ester;Benzeneacetic acid, alpha-phenyl-, methyl ester;Methyldiphenylacetate98%;Methyldiphenylacetate 98%
• CAS NO: 3469-00-9
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27
• EINECS: 222-431-5
• Product Categories: C12 to C63;Carbonyl Compounds;Esters;Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 3469-00-9.mol
• Article Data: 56

Chemical Properties

• Melting Point: 59-62 °C(lit.)
• Boiling Point: 321.4 °C at 760 mmHg
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 0.000299mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Soluble in methanol.
• CAS DataBase Reference: METHYL DIPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL DIPHENYLACETATE(3469-00-9)
• EPA Substance Registry System: METHYL DIPHENYLACETATE(3469-00-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 3469-00-9(Hazardous Substances Data)

Usage

Description

Methyl diphenylacetate, also known as methyl 2,2-diphenylacetate, is an organic compound that serves as a chemical intermediate and a useful research chemical in various applications across different industries.

Uses

Used in Chemical Industry:
Methyl diphenylacetate is used as a chemical intermediate for the synthesis of various organic compounds and pharmaceuticals. Its unique structure allows it to be a versatile building block in the development of new molecules and materials.
Used in Research and Development:
As a research chemical, methyl diphenylacetate is utilized in academic and industrial laboratories for the investigation of its properties and potential applications. It can be employed in the study of organic reactions, synthesis methods, and the development of new chemical processes.
Used in Pharmaceutical Industry:
Methyl diphenylacetate may also be used in the pharmaceutical industry as a starting material or intermediate in the production of various drugs and medications. Its unique structure can contribute to the development of new therapeutic agents with improved efficacy and safety profiles.

Synthesis Reference(s)

Tetrahedron, 46, p. 1839, 1990 DOI: 10.1016/S0040-4020(01)89753-2Tetrahedron Letters, 25, p. 4943, 1984 DOI: 10.1016/S0040-4039(01)91265-1

InChI:InChI=1/C15H14O2/c1-17-15(16)14(12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 117-34-0 2,2-diphenylacetic acid 
• 67-56-1 methanol 
• 384-94-1 1,1'-(2,2,2-trifluoro-1,1-ethanediyl)dibenzene 
• 124-41-4 sodium methylate 
• 6632-43-5 methyl α-acetoxy-α-phenylbenzeneacetate 
• 501-65-5 diphenyl acetylene 
• 3469-17-8 2-diazo-1,2-diphenylethan-1-one 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 71-43-2 benzene 
• 58007-70-8 Diethylthiocarbamoylsulfanyl-diphenyl-acetic acid methyl ester 
• 15745-93-4 triphenyl-azetidine-2,4-dione 
• 54311-64-7 methyl α-chloro-α-phenylbenzeneacetate 
• 25327-58-6 Benzoic diphenylacetic anhydride 

Downstream Products

• 7476-11-1 1,1,3,3-tetraphenylpropane-2-one 
• 72727-35-6 2,2,N-triphenyl-3-thio-malonamic acid methyl ester 
• 13027-73-1 methyl 2-cyclohexyl-2-phenylacetate 
• 83004-43-7 methyl 2,2-bis(4-nitrophenyl)ethanoate 
• 104488-36-0 Bromdiphenylessigsaeure-methylester 
• 7770-42-5 diphenyl-malonic acid dimethyl ester 
• 93008-37-8 N-(2-Hydroxyethyl)-2,2-diphenylacetamid 
• 24056-59-5 3,3-Diphenylpiperidin-2-one 
• 31469-19-9 diphenyl-2,2 methoxy-1 trimethylsiloxy-1 ethylene 
• 57272-44-3 methyl α-hydroperoxy-α,α-diphenylacetate 
• 123172-65-6 4-Hydroxy-3,3-diphenyl-dihydro-furan-2-one 
• 84960-26-9 2,6-bis(α-phenyl-α-carbomethoxybenzyl)pyridine 
• 91614-23-2 Diphenyl-acetic acid 1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-piperidin-4-yl ester 
• 51552-62-6 methoxy-diphenyl-acetic acid methyl ester 

Relevant articles and documents

Iodoarene-Catalyzed Oxyamination of Unactivated Alkenes to Synthesize 5-Imino-2-Tetrahydrofuranyl Methanamine Derivatives

Reported here is the room-temperature metal-free iodoarene-catalyzed oxyamination of unactivated alkenes. In this process, the alkenes are difunctionalized by the oxygen atom of the amide group and the nitrogen in an exogenous HNTs2 molecule. This mild and open-air reaction provided an efficient synthesis to N-bistosyl-substituted 5-imino-2-tetrahydrofuranyl methanamine derivatives, which are important motifs in drug development and biological studies. Mechanistic study based on experiments and density functional theory calculations showed that this transformation proceeds via activation of the substrate alkene by an in situ generated cationic iodonium(III) intermediate, which is subsequently attacked by an oxygen atom (instead of nitrogen) of amides to form a five-membered ring intermediate. Finally, this intermediate undergoes an SN2 reaction by NTs2 as the nucleophile to give the oxygen and nitrogen difunctionalized 5-imino-2-tetrahydrofuranyl methanamine product. An asymmetric variant of the present alkene oxyamination using chiral iodoarenes as catalysts also gave promising results for some of the substrates.

Photoredox Catalytic Phosphite-Mediated Deoxygenation of α-Diketones Enables Wolff Rearrangement and Staudinger Synthesis of β-Lactams

A novel visible-light-driven catalytic activation of C=O bonds by exploiting the photoredox chemistry of 1,3,2-dioxaphospholes, readily accessible from α-diketones and trialkyl phosphites, is reported. This mild and environmentally friendly strategy provides an unprecedented and efficient access to the Wolff rearrangement reaction which traditionally entails α-diazoketones as precursors. The resulting ketenes could be precisely trapped by alcohols/thiols to give α-aryl (thio)acetates and by imines to afford the valuable β-lactams in up to 99 % yields.